4.6 Article

Alteration of RNA modification signature in human sperm correlates with sperm motility

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

m6A reader protein YTHDF2 regulates spermatogenesis by timely clearance of phase-specific transcripts

Meijie Qi et al.

Summary: The study demonstrated the critical role of YTHDF2 in spermatogenesis by showing that YTHDF2 knockout led to male infertility and affected sperm morphology, motility, and fertilization ability. YTHDF2 facilitates timely turnover of stage-specific transcripts to ensure proper progression of spermatogenesis.

CELL PROLIFERATION (2022)

Article Multidisciplinary Sciences

RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes

Hui Ma et al.

Summary: This study found that RAD51AP2 plays a specific role in the formation of crossovers on XY chromosomes in the pseudoautosomal region, and its mutation leads to compromised DSB repair in PARs.

SCIENCE ADVANCES (2022)

Review Physiology

SPERM BAUPLAN AND FUNCTION AND UNDERLYING PROCESSES OF SPERM FORMATION AND SELECTION

Maria Eugenia Teves et al.

Summary: Sperm is a highly differentiated and polarized cell with two main structures: the head and the flagellum. Despite having the same function, there is a great diversity in the structure and performance of sperm cells. This diversity may be related to the mechanisms of transport, fertilization preparation, and interaction with the oocyte.

PHYSIOLOGICAL REVIEWS (2022)

Review Obstetrics & Gynecology

A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships

Brendan J. Houston et al.

Summary: Research has shown a significant genetic component in male infertility, particularly monogenic causes. The field had been slow in adopting next-generation sequencing technologies and lacked clear statements on validated causes of human male infertility. Through clinical validity assessment, 120 genes were identified to be moderately, strongly or definitively linked to 104 infertility phenotypes.

HUMAN REPRODUCTION UPDATE (2022)

Article Cell Biology

Exploring the expanding universe of small RNAs

Junchao Shi et al.

Summary: This article discusses recent approaches for discovering sncRNAs, limitations associated with sncRNA expression analyses, and emerging methods for direct and simultaneous detection of multiple RNA modifications.

NATURE CELL BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm

Marcos Morgan et al.

Summary: Multiple RNA pathways are essential in producing functional sperm, with a particular focus on 3' end modifications. Studies have shown a correlation between RNA 3' end metabolism and male germ cell differentiation, as well as the importance of RNA pathways in maintaining genomic integrity.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Medicine, General & Internal

Male infertility

Ashok Agarwal et al.

Summary: Infertility affects 8-12% of couples globally, with male factors contributing to around 50%. The causes of male infertility are diverse, requiring thorough evaluation to identify treatable or reversible factors. Semen analysis is key for evaluation, while advanced tests have been developed to investigate sperm quality and function.

LANCET (2021)

Review Agriculture, Dairy & Animal Science

Aberrant regulation of RNA methylation during spermatogenesis

Dandan Zhong et al.

Summary: This review summarizes the typical characteristics of different types of RNA methylation during spermatogenesis and highlights the functions of RNA methylation effectors during male germ cell development.

REPRODUCTION IN DOMESTIC ANIMALS (2021)

Article Genetics & Heredity

Homozygous mutations in C14orf39/SIX6OS1 cause non-obstructive azoospermia and premature ovarian insufficiency in humans

Suixing Fan et al.

Summary: The study identified mutations in the SC coding gene C14orf39/SIX6OS1 that cause infertility in humans. These mutations affect the assembly of the synaptonemal complex and were found to lead to asynapsis or incomplete synapsis during meiosis in affected individuals. The findings highlight a conserved role of C14ORF39/SIX6OS1 in fertility and expand our understanding of the genetic basis of human infertility.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

Article Biochemistry & Molecular Biology

Cross-talk of four types of RNA modification writers defines tumor microenvironment and pharmacogenomic landscape in colorectal cancer

Huifang Chen et al.

Summary: Our study provides a comprehensive analysis of four RNA modifications in CRC and reveals the potential functions of these writers in TME, transcriptional and post-transcriptional events. The study also identifies the therapeutic implications of targeting these writers in cancer therapy, highlighting their potential clinical utility in targeted therapy and immunotherapy.

MOLECULAR CANCER (2021)

Article Multidisciplinary Sciences

METTL3 regulates heterochromatin in mouse embryonic stem cells

Wenqi Xu et al.

Summary: METTL3 regulates mouse embryonic stem-cell heterochromatin, critical for silencing retroviral elements and mammalian development. Through m(6)A methylation, METTL3 modulates integrity of IAP heterochromatin.

NATURE (2021)

Article Biochemistry & Molecular Biology

SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs

Guofang Hou et al.

Summary: Our study reveals that YTHDF2 can be SUMOylated, playing a crucial role in cancer progression.

NUCLEIC ACIDS RESEARCH (2021)

Review Biochemistry & Molecular Biology

Origins and evolving functionalities of tRNA-derived small RNAs

Qi Chen et al.

Summary: tsRNA, derived from tRNA cleavage, are ancient small RNAs with versatile roles in fundamental biological processes. These roles stem from sequence conservation, RNA modifications, and protein-binding abilities, suggesting the need for expanding tsRNA research into broader areas for precision medicine.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

Epigenetic regulations in mammalian spermatogenesis: RNA-m6A modification and beyond

Yiqian Gui et al.

Summary: The m(6)A modification plays a critical role in spermatogenesis, affecting different stages of male germ cell development. It is involved in RNA metabolism, impacted by environmental exposure, and capable of being inherited across generations.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Cell Biology

PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Junchao Shi et al.

Summary: Shi et al. profiled small non-coding RNAs (sncRNAs) through PANDORA-seq, identifying tissue-specific transfer RNA- and ribosomal RNA-derived small RNAs, as well as sncRNAs with dynamic changes during induced pluripotent stem cell reprogramming.

NATURE CELL BIOLOGY (2021)

Review Genetics & Heredity

The epitranscriptome beyond m6A

David Wiener et al.

Summary: This Perspective reviews efforts to map six different RNA modifications and how they differ from N-6-methyladenosine. The authors discuss technical and analytical challenges of characterizing the epitranscriptome and provide their conclusions on the abundance and distribution of these modifications. The article highlights commonalities and differences among the modifications in comparison to m(6)A, speculating on their origins and functional abilities over evolutionary timescales.

NATURE REVIEWS GENETICS (2021)

Article Immunology

A DNAH17 missense variant causes flagella destabilization and asthenozoospermia

Beibei Zhang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice

Xin Wang et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Coordination of mRNA and tRNA methylations by TRMT10A

R. Jordan Ontiveros et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Oncology

Role of RNA modifications in cancer

Isaia Barbieri et al.

NATURE REVIEWS CANCER (2020)

Article Genetics & Heredity

A homozygous FANCM frameshift pathogenic variant causes male infertility

Hao Yin et al.

GENETICS IN MEDICINE (2019)

Review Multidisciplinary Sciences

Advances in epigenetics link genetics to the environment and disease

Giacomo Cavalli et al.

NATURE (2019)

Article Endocrinology & Metabolism

Sperm RNA code programmes the metabolic health of offspring

Yunfang Zhang et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Daniel N. Weinberg et al.

NATURE (2019)

Article Obstetrics & Gynecology

Sperm microRNA pairs: new perspectives in the search for male fertility biomarkers

Celia Corral-Vazquez et al.

FERTILITY AND STERILITY (2019)

Article Biochemistry & Molecular Biology

MODOMICS: a database of RNA modification pathways. 2017 update

Pietro Boccaletto et al.

NUCLEIC ACIDS RESEARCH (2018)

Review Urology & Nephrology

Sexual dysfunction and male infertility

Francesco Lotti et al.

NATURE REVIEWS UROLOGY (2018)

Review Urology & Nephrology

Genetics of male infertility

Csilla Krausz et al.

NATURE REVIEWS UROLOGY (2018)

Review Multidisciplinary Sciences

RNA modifications modulate gene expression during development

Michaela Frye et al.

SCIENCE (2018)

Editorial Material Cell Biology

HSC function determined by epigenetic memory

Kirsty Minton

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Cell Biology

RNA modifications and structures cooperate to guide RNA-protein interactions

Cole J. T. Lewis et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Dynamic RNA Modifications in Gene Expression Regulation

Ian A. Roundtree et al.

Review Urology & Nephrology

Comorbidities and male infertility: a worrisome picture

Eugenio Ventimiglia et al.

CURRENT OPINION IN UROLOGY (2016)

Review Genetics & Heredity

RNA modifications: what have we learned and where are we headed?

Michaela Frye et al.

NATURE REVIEWS GENETICS (2016)

Review Genetics & Heredity

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

Qi Chen et al.

NATURE REVIEWS GENETICS (2016)

Article Urology & Nephrology

High Quality RNA in Semen and Sperm: Isolation, Analysis and Potential Application in Clinical Testing

Andrew P. Georgiadis et al.

JOURNAL OF UROLOGY (2015)

Article Cell Biology

Absence of sperm RNA elements correlates with idiopathic male infertility

Meritxell Jodar et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Obstetrics & Gynecology

The combined human sperm proteome: cellular pathways and implications for basic and clinical science

Alexandra Amaral et al.

HUMAN REPRODUCTION UPDATE (2014)

Review Obstetrics & Gynecology

The presence, role and clinical use of spermatozoal RNAs

Meritxell Jodar et al.

HUMAN REPRODUCTION UPDATE (2013)

Article Biochemistry & Molecular Biology

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

Shobbir Hussain et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

Article Obstetrics & Gynecology

Differential RNAs in the sperm cells of asthenozoospermic patients

Meritxell Jodar et al.

HUMAN REPRODUCTION (2012)

Review Chemistry, Multidisciplinary

Cellular Dynamics of RNA Modification

Chengqi Yi et al.

ACCOUNTS OF CHEMICAL RESEARCH (2011)

Article Obstetrics & Gynecology

World Health Organization reference values for human semen characteristics

Trevor G. Cooper et al.

HUMAN REPRODUCTION UPDATE (2010)

Review Genetics & Heredity

Paternal contribution: New insights and future challenges

SA Krawetz

NATURE REVIEWS GENETICS (2005)

Article Biochemistry & Molecular Biology

The controversy, potential and roles of spermatozoal RNA

D Miller et al.

TRENDS IN MOLECULAR MEDICINE (2005)