4.5 Article

Dependence on the MUC1-C Oncoprotein in Classic, Variant, and Non-neuroendocrine Small Cell Lung Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

Advances in Small-Cell Lung Cancer (SCLC) Translational Research

Benjamin J. Drapkin et al.

Summary: In recent years, there has been a renewed interest in the biology and therapeutic vulnerabilities of small-cell lung cancer (SCLC), leading to the development of diverse models and translational research avenues. These offer new hope for patients with SCLC by combining mechanism-based preclinical and clinical research.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2021)

Article Oncology

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Carl M. Gay et al.

Summary: Despite the heterogeneity of small cell lung cancer (SCLC), four subtypes have been identified based on tumor expression data, each showing different responses to treatment. SCLC-I subtype benefits the most from immunotherapy, while other subtypes have vulnerabilities to different inhibitors. Matching tumor subtype to therapy and manipulating subtype switching during treatment may enhance response depth and duration for SCLC patients.

CANCER CELL (2021)

Article Oncology

MUC1-C Activates the BAF (mSWI/SNF) Complex in Prostate Cancer Stem Cells

Masayuki Hagiwara et al.

Summary: MUC1-C associates with E2F1 and activates a novel pathway related to prostate cancer stem cell function.

CANCER RESEARCH (2021)

Article Oncology

Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer

Joseph M. Chan et al.

Summary: The study reveals a greater tumor diversity in SCLC compared to lung adenocarcinoma, with a PLCG2-high SCLC phenotype showing stem-like, pro-metastatic features and predicting worse overall survival. Furthermore, SCLC demonstrates greater immune sequestration and less immune infiltration than lung adenocarcinoma.

CANCER CELL (2021)

Article Medicine, General & Internal

Small-cell lung cancer

Charles M. Rudin et al.

Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.

NATURE REVIEWS DISEASE PRIMERS (2021)

Article Oncology

MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer

Nami Yamashita et al.

Summary: The study demonstrates that MUC1-C is a key regulator of the TNBC transcriptome through activation of the IFN-gamma pathway, leading to immunosuppression and depletion of TILs in the TNBC TIME. MUC1-C may be a potential target for improving TNBC treatment, especially in combination with ICIs, and is already being explored as a target for CAR T cells and ADCs in clinical development.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Oncology

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

Anish Thomas et al.

Summary: Inhibiting ATR, the primary activator of replication stress, and TOP1, which suppresses genomic instability, synergistically showed cytotoxic effects in small cell lung cancer. The combination of ATR inhibitor M6620 and TOP1 inhibitor topotecan achieved a 36% objective response rate in SCLC patients, with durable tumor regressions observed in platinum-resistant SCNCs. These findings suggest that replication stress may be a transformative vulnerability in SCNCs, allowing for rational patient selection and potential personalized treatment strategies.

CANCER CELL (2021)

Article Multidisciplinary Sciences

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

Yota Yasumizu et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Lineage plasticity in cancer: a shared pathway of therapeutic resistance

Alvaro Quintanal-Villalonga et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Respiratory System

Smoking-associated increase in mucins 1 and 4 in human airways

Heta Merikallio et al.

RESPIRATORY RESEARCH (2020)

Article Biochemistry & Molecular Biology

Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch

Youcef Ouadah et al.

Review Biochemistry & Molecular Biology

Triggering mitosis

Adrijana Crncec et al.

FEBS LETTERS (2019)

Review Oncology

The broken cycle: E2F dysfunction in cancer

Lindsey N. Kent et al.

NATURE REVIEWS CANCER (2019)

Article Biochemistry & Molecular Biology

Recovering Gene Interactions from Single-Cell Data Using Data Diffusion

David van Dijk et al.

Review Genetics & Heredity

Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

Yejing Ge et al.

NATURE REVIEWS GENETICS (2018)

Article Oncology

Replication stress response in cancer stem cells as a target for chemotherapy

Gwenola Manic et al.

SEMINARS IN CANCER BIOLOGY (2018)

Article Medicine, Research & Experimental

Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate

Govind Panchamoorthy et al.

JCI INSIGHT (2018)

Article Biochemical Research Methods

SCENIC: single-cell regulatory network inference and clustering

Sara Aibar et al.

NATURE METHODS (2017)

Editorial Material Cell Biology

Small cell lung cancer: Time to revisit DNA-damaging chemotherapy

Anish Thomas et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Myc and cell cycle control

Gabriel Bretones et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)

Article Biotechnology & Applied Microbiology

Spatial reconstruction of single-cell gene expression data

Rahul Satija et al.

NATURE BIOTECHNOLOGY (2015)

Article Cell Biology

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles

Huayang Liu et al.

NATURE CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target

Deepak Raina et al.

PLOS ONE (2015)

Article Biochemistry & Molecular Biology

Revisiting Global Gene Expression Analysis

Jakob Loven et al.

Article Oncology

Dependence on the MUC1-C Oncoprotein in Non-Small Cell Lung Cancer Cells

Deepak Raina et al.

MOLECULAR CANCER THERAPEUTICS (2011)

Article Oncology

MUC1 oncoprotein is a druggable target in human prostate cancer cells

Maya Datt Joshi et al.

MOLECULAR CANCER THERAPEUTICS (2009)

Review Oncology

Oncogene addiction

I. Bernard Weinstein et al.

CANCER RESEARCH (2008)