4.5 Review

The interplay of cytokine signaling and non-coding RNAs in head and neck squamous cell carcinoma pathobiology

期刊

MOLECULAR BIOLOGY REPORTS
卷 49, 期 11, 页码 10825-10847

出版社

SPRINGER
DOI: 10.1007/s11033-022-07770-x

关键词

lncRNA; miRNA; circRNA; HNSCC; Cytokines; Chemokines

资金

  1. OPERA Grant from BITS Pilani-Hyderabad Campus
  2. CHDR Grant from BITS Pilani-Hyderabad Campus
  3. ICMR [2021-10878]
  4. DST Inspire fellowship [IF190343]

向作者/读者索取更多资源

Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related death worldwide, and recurrence poses a challenge. Cytokines play a crucial role in promoting HNSCC growth and anti-tumor immune response, while non-coding RNAs (ncRNAs) also play a key role in regulating cytokine function.
Head and neck squamous cell carcinoma (HNSCC) is a leading cause of cancer-related death worldwide. Despite aggressive treatment approaches, the recurrence of HNSCC remains a challenge. Cytokines play an essential role in HNSCC development and progression. They are not only involved in promoting cancer growth but may also be involved in an anti-tumor immune response. Non-coding RNAs (ncRNAs) have emerged as important transcriptional and post-transcriptional mediators of cytokine function in HNSCC. This review focuses on the complex regulatory network among regulatory ncRNAs and cytokines during HNSCC pathogenesis.

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