Multidrug-resistant infections in solid organ transplant recipients: a focus on risk factors, prevention, and treatment strategies

Solid organ transplantation is the best therapeutic option for patients with end-stage organ disease and, according to the data from international registries, there has been a steady increase in numbers and results. However, post-transplant infec-tions remain a fearsome complication with, in the last decade, an increasing incidence of episodes due to antibiotic -resis-tant bacteria and opportunistic agents. In this paper, we summarized the most relevant and updated knowledge concerning infections from multidrug-resistant germs in solid organ transplant recipients, focusing on risk factors, treatment and prevention strategies, and antimicrobial pharmacokinetics relevant to this population of patients.

Automated summary

Solid organ transplantation is the best therapeutic option for patients with end-stage organ disease. However, infections remain a serious complication, with an increasing incidence of episodes due to antibiotic-resistant bacteria and opportunistic agents.