4.5 Article

Antibacterial and antibiotic modifying activity of chalcone (2E)-1-(4'-aminophenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one in strains of Staphylococcus aureus carrying NorA and MepA efflux pumps: In vitro and in silico approaches

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties

Bilal Litim et al.

Summary: Novel alpha-aminophosphonates derivatives incorporating quinoline or quinolone, and coumarylthiazole or 5-phenylthiazol-2-amine moieties were synthesized and screened for antimicrobial activity. The compounds showed moderate to strong inhibitory activities against Gram-positive and Gram-negative bacteria, with some exhibiting excellent antifungal inhibition. Structure-activity relationship analysis indicated that certain structural moieties enhanced the inhibitory activity against microbial pathogens, suggesting the synthesized compounds as potential antimicrobial drug candidates.

MEDICINAL CHEMISTRY RESEARCH (2022)

Article Materials Science, Biomaterials

In vitro synergic activity of diethyldithiocarbamate and 4-nitrochalcone loaded in beeswax nanoparticles against melanoma (B16F10) cells

Arthur Poester Cordeiro et al.

Summary: The study aimed to encapsulate sodium diethyldithiocarbamate (DETC) and 4-nitrochalcone (4NC) in beeswax nanoparticles (BNs) to evaluate the synergistic activity against melanoma cells. The results showed that DETC and 4NC loaded in BNs exhibited higher cytotoxicity towards B16F10 cells and the simultaneous encapsulation led to a synergistic effect on cell viability.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Multidisciplinary Sciences

Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae

Nousheen Parvaiz et al.

Summary: This study explores the use of combination therapy to identify novel beta-lactamase inhibitors that can inactivate the enzyme of pathogens, providing a new approach in combating multi-drug resistant pathogens. By utilizing computational screening and experimental validation, potential compounds were identified with beta-lactamase inhibition and antibacterial activity against MDR clinical isolates. These non-beta-lactam-based inhibitors have the potential to be used in combination therapy with beta-lactam antibiotics against resistant strains.

PLOS ONE (2021)

Article Chemistry, Multidisciplinary

Synthesis and biological activity of new chalcone scaffolds as prospective antimicrobial agents

Sangeeta Narwal et al.

Summary: A series of chalcone derivatives were synthesized and evaluated for their in vitro antimicrobial activity, showing promising results against both Gram-positive and Gram-negative bacterial and fungal strains, comparable to standard drugs.

RESEARCH ON CHEMICAL INTERMEDIATES (2021)

Article Pharmacology & Pharmacy

Aminophenyl chalcones potentiating antibiotic activity and inhibiting bacterial efflux pump

Marina Micaele Rodrigues Siqueira et al.

Summary: Chalcones and their derivatives hold great potential in combating bacterial resistance, with different antibiotic modifying effects observed on Staphylococcus aureus and Escherichia coli.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Chemistry, Physical

Synthesis, spectroscopic characterization and antibacterial evaluation by chalcones derived of acetophenone isolated from Croton anisodontus Mull.Arg.

P. T. da Silva et al.

Summary: Chalcones and their derivatives were synthesized and characterized, with their molecular structures elucidated using various spectroscopic techniques. The compounds showed potential as adjuvants to antibiotics in treating infections caused by S. aureus, by potentiating the antibiotic activity against specific bacterial strains. The study also investigated the mechanism of efflux pump inhibition and the molecular interactions of the chalcones.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Pharmacology & Pharmacy

Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone

Monika Kadela-Tomanek et al.

Summary: The research demonstrated the importance of lipophilicity in the design of new active compounds, as well as the impact of lipophilicity on the pharmacodynamic and toxicological properties of compounds. Computer programs and molecular docking studies showed a correlation between molecular structure and properties.

PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Virtual Screening of Citrus Flavonoid Tangeretin: A Promising Pharmacological Tool for the Treatment and Prevention of Zika fever and COVID-19

Matheus Nunes da Rocha et al.

Summary: The study investigated the potential of Tangeritin as a therapeutic drug for Zika fever and COVID-19, analyzing its stability, lack of reactivity, and strong interactions with viral receptors. The findings suggest that Tangerentin is a promising pharmacological tool for these viral diseases, with minimal drug alterations and low risk of toxicity to patients.

JOURNAL OF COMPUTATIONAL BIOPHYSICS AND CHEMISTRY (2021)

Review Chemistry, Multidisciplinary

Chalcone synthesis, properties and medicinal applications: a review

Aluru Rammohan et al.

ENVIRONMENTAL CHEMISTRY LETTERS (2020)

Article Chemistry, Medicinal

Synthesis, structural characterization, and cytotoxic evaluation of chalcone derivatives

Paulo N. Bandeira et al.

MEDICINAL CHEMISTRY RESEARCH (2019)

Article Biochemistry & Molecular Biology

UniProt: a worldwide hub of protein knowledge

Alex Bateman et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Immunology

Efflux pump inhibitors for bacterial pathogens: From bench to bedside

Atin Sharma et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2019)

Article Chemistry, Medicinal

Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates

Pinki Yadav et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Chemistry, Multidisciplinary

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives

Mingming Zhang et al.

ACS OMEGA (2018)

Review Chemistry, Multidisciplinary

Synthesis and pharmacological properties of chalcones: a review

Santosh L. Gaonkar et al.

RESEARCH ON CHEMICAL INTERMEDIATES (2017)

Article Biochemistry & Molecular Biology

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

Travis T. Wager et al.

ACS CHEMICAL NEUROSCIENCE (2016)

Article Chemistry, Medicinal

Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope

Denis Mulliner et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2016)

Review Pharmacology & Pharmacy

Multidrug efflux pumps of Gram-positive bacteria

Bryan D. Schindler et al.

DRUG RESISTANCE UPDATES (2016)

Article Multidisciplinary Sciences

Structural basis for the blockade of MATE multidrug efflux pumps

Martha Radchenko et al.

NATURE COMMUNICATIONS (2015)

Article Chemistry, Medicinal

Improving the Odds of Success in Drug Discovery: Choosing the Best Compounds for in Vivo Toxicology Studies

Travis T. Wager et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

Daohua Jiang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

Arup K. Ghose et al.

ACS CHEMICAL NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

Jes Gitz Holler et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Exploring Pharmacological Significance of Chalcone Scaffold: A Review

N. K. Sahu et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Article Chemistry, Medicinal

In silico Prediction of Chemical Ames Mutagenicity

Congying Xu et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Biochemical Research Methods

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

Michael Remmert et al.

NATURE METHODS (2012)

Article Chemistry, Multidisciplinary

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

Marcus D. Hanwell et al.

JOURNAL OF CHEMINFORMATICS (2012)

Article Chemistry, Medicinal

A bioavailability score

YC Martin

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Chemistry, Medicinal

A structure-permeability study of small drug-like molecules

T Fichert et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)

Article Chemistry, Medicinal

Molecular properties that influence the oral bioavailability of drug candidates

DF Veber et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)

Review Pharmacology & Pharmacy

Prediction of intestinal permeability

WJ Egan et al.

ADVANCED DRUG DELIVERY REVIEWS (2002)