期刊
MEDICAL AND VETERINARY ENTOMOLOGY
卷 36, 期 4, 页码 486-495出版社
WILEY
DOI: 10.1111/mve.12593
关键词
Aedes aegypti; chikungunya virus; deltamethrin; insecticide resistance; Vector competence
资金
- Agence Nationale de la Recherche [ANR-10-LABEX-0025]
- French Guiana Region [FEDER-CONTROLE, GY0010695]
- International Direction of Institut Pasteur [2015-2017]
- European Union
This study found three mosquito lines with different resistance profiles to deltamethrin in French Guiana, and observed significant differences in their ability to carry and transmit the chikungunya virus. Furthermore, certain genes related to resistance were found to be variably overexpressed in the midgut of mosquitoes after an infectious bloodmeal. These findings contribute to a better understanding of the relationship between mosquito resistance and vector competence.
The urban mosquito species Aedes aegypti is the main vector of arboviruses worldwide. Mosquito control with insecticides is the most prevalent method for preventing transmission in the absence of effective vaccines and available treatments; however, the extensive use of insecticides has led to the development of resistance in mosquito populations throughout the world, and the number of epidemics caused by arboviruses has increased. Three mosquito lines with different resistance profiles to deltamethrin were isolated in French Guiana, including one with the I1016 knock-down resistant allele. Significant differences were observed in the cumulative proportion of mosquitoes with a disseminated chikungunya virus infection over time across these lines. In addition, some genes related to resistance (CYP6BB2, CYP6N12, GST2, trypsin) were variably overexpressed in the midgut at 7 days after an infectious bloodmeal in these three lines. Our work shows that vector competence for chikungunya virus varied between Ae. aegypti laboratory lines with different deltamethrin resistance profiles. More accurate verification of the functional association between insecticide resistance and vector competence remains to be demonstrated.
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