期刊
MATERIALS & DESIGN
卷 220, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2022.110890
关键词
Quantum dots; Polyethylenimine; Drug delivery system; Bio-imaging; Tumor treatment
资金
- National Natural Science Foundation of China [21501044]
- Natural Science Founda-tion of Henan Province [222300420411]
- Key Scientific and Tech-nological Project of Henan Province [212102311018]
- Major Cultivation Project of First-class Discipline of Henan University [2019YLZDJL09]
- Special Professor Project of Henan University
In this study, the research team developed a CdSe/ZnS quantum dot nano-drug delivery system that efficiently inhibited the proliferation of various cancer cells. The system exerted anti-cancer effects through the regulation of reactive oxygen species and protein expression, and showed promising therapeutic efficacy and biosafety in a mouse model.
Quantum dots (QDs) receive widespread attention for delivery of drugs, probing and bio-imaging exploit -ing their unique properties. Herein, we developed CdSe/ZnS QDs by modified low molecular weight poly-ethyleneimine (PEI) and conjugated them covalently with anticancer drug 10-hydroxycamptothecin (HCPT) to form a nano-drug delivery system (CdSe/ZnS@PEI-cHCPT). CdSe/ZnS@PEI-cHCPT could effi-ciently inhibit the proliferation of HeLa as well as other cancer cells. Moreover, CdSe/ZnS@PEI-cHCPT mediated formation of excessive reactive oxygen species (ROS), down regulation of the expression of Bcl-2 protein and up regulation of the expression of P53, Bak and PARP-1 proteins were found to be the molecular mechanisms underlying the effective anti-cancer potential of the nano-drug delivery sys-tem. Further, CdSe/ZnS@PEI-cHCPT displayed efficient therapeutic effect in inhibiting tumor growth in mice and had good biosafety and effectively enriched at the tumor site to improve the treatment effect, suggesting their great potential for future biomedical applications. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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