期刊
MASS SPECTROMETRY REVIEWS
卷 42, 期 3, 页码 1032-1062出版社
WILEY
DOI: 10.1002/mas.21786
关键词
biomarkers; estrogenic retina; photobiology; posttranslational modifications; protein expression; proteomics; retina; retinal diseases; therapeutic targets
类别
This article provides an in-depth overview of the development and contribution of retina proteomics, with a focus on the role of mass spectrometry in advancing research in this field.
A subfield of neuroproteomics, retina proteomics has experienced a transformative growth since its inception due to methodological advances in enabling chemical, biochemical, and molecular biology techniques. This review focuses on mass spectrometry's contributions to facilitate mammalian and avian retina proteomics to catalog and quantify retinal protein expressions, determine their posttranslational modifications, as well as its applications to study the proteome of the retina in the context of biology, health and diseases, and therapy developments.
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