4.5 Review

Mass spectrometry-based retina proteomics

期刊

MASS SPECTROMETRY REVIEWS
卷 42, 期 3, 页码 1032-1062

出版社

WILEY
DOI: 10.1002/mas.21786

关键词

biomarkers; estrogenic retina; photobiology; posttranslational modifications; protein expression; proteomics; retina; retinal diseases; therapeutic targets

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This article provides an in-depth overview of the development and contribution of retina proteomics, with a focus on the role of mass spectrometry in advancing research in this field.
A subfield of neuroproteomics, retina proteomics has experienced a transformative growth since its inception due to methodological advances in enabling chemical, biochemical, and molecular biology techniques. This review focuses on mass spectrometry's contributions to facilitate mammalian and avian retina proteomics to catalog and quantify retinal protein expressions, determine their posttranslational modifications, as well as its applications to study the proteome of the retina in the context of biology, health and diseases, and therapy developments.

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