期刊
MARINE DRUGS
卷 20, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md20070443
关键词
starfish-derived fungus; Penicillium sp; citrinin dimers; antifungal activities; cytotoxic activities; protein-protein interaction network
资金
- Special Project for Marine Economic Development of Department of Natural Resources of Guangdong Province [GDNRC [2021]48, GDNRC [2020]039]
- National Natural Science Foundation of China [81741160]
- Science and Technology Planning Project of Guangdong Province [2017A020217008, 2015A020216017]
Four novel carbon-bridged citrinin dimers were isolated from starfish-derived fungus, exhibiting strong antifungal activities and significant cytotoxicity against human pancreatic cancer cells.
Four novel, rare carbon-bridged citrinin dimers, namely dicitrinones G-J (1-4), and five known analogs (5-9) were isolated from the starfish-derived fungus Penicillium sp. GGF 16-1-2. Their structures were elucidated by extensive spectroscopic analysis and quantum chemical calculations. Compounds 1-9 exhibited strong antifungal activities against Colletotrichum gloeosporioides with LD50 values from 0.61 mu g/mL to 16.14 mu g/mL. Meanwhile, all compounds were evaluated for their cytotoxic activities against human pancreatic cancer BXPC-3 and PANC-1 cell lines; as a result, compound 1 showed more significant cytotoxicities than the positive control against both cell lines. In addition, based on the analyses of the protein-protein interaction (PPI) network and Western blot, 1 could induce apoptosis by activating caspase 3 proteins (CASP3).
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