Comparison of primary liver cancer mortality estimates from World Health Organization, global burden disease and global cancer observatory

Aims This study aims to compare estimates of primary liver cancer mortality from World Health Organization (WHO), Global Burden Disease (GBD) and Global Cancer Observatory (GCO). Methods Liver cancer mortality was extracted from WHO, GBD and GCO for 92 countries for the most recent year. Age-standardized rate (ASR) was computed and used for current comparisons across the three data sources. Temporal trend for 75 countries was analysed and compared between WHO and GBD from 1990 to 2019 using joinpoint regression. Average annual percentage change for the most recent 10 years was used as indicator for change. Results The estimates of ASR were quite consistent across the three data sources, but most similar estimates were found between WHO and GCO in both region and country levels. The differences in ASR were negatively correlated with completeness of cause-of-death registration, human development index and proportion of liver cancer because of alcohol consumption. Consistent trends of ASR were found from 35 countries between WHO and GBD in the most recent 10 years. However, opposite trends were found from 10 countries with five from Southern America, four from Europe and one from Asia. Of the 18 countries for projection, opposite trends between WHO and GBD were found from seven countries. Conclusion While the ASR of primary liver cancer mortality was comparable across the three data sources, most similar estimates were found between WHO and GCO. The opposite trends found from 10 countries between WHO and GBD raised concerns of true patterns in these countries.

Automated summary

This study aimed to compare estimates of primary liver cancer mortality from the World Health Organization (WHO), Global Burden Disease (GBD), and Global Cancer Observatory (GCO). The study found that while the age-standardized rates (ASR) of primary liver cancer mortality were comparable across the three data sources, the most similar estimates were found between WHO and GCO. Concerns were raised about the true patterns of liver cancer mortality in certain countries due to opposite trends between WHO and GBD in some cases.