期刊
LEUKEMIA & LYMPHOMA
卷 63, 期 12, 页码 2948-2954出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428194.2022.2102621
关键词
Asparaginase toxicity; hypersensitivity; hyperbilirubinemia; pancreatitis; venous thromboembolism
资金
- National Institutes of Health National Cancer Institute [P20CA262733, K07CA218362]
- Cancer Prevention Research Institute of Texas [RP160771, RP170668]
- St. Baldrick's Foundation Consortium Research Grant [522277]
- Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium
- Cancer Prevention and Research Institute of Texas
- St. Baldrick's Foundation
This study retrospectively analyzed 548 patients with acute lymphoblastic leukemia and found that older age, overweight, and treatment intensity increased the risk of pegaspargase-associated toxicities.
A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3%). Odds ratios (OR) and 95% confidence intervals (CI) evaluated associations between clinical factors and each toxicity, cumulative number of toxicities, and toxicity clusters identified using k-mode analysis. Most (68.9%) did not experience any toxicity, 24.6% experienced one toxicity, and 6.3% two or more. Age >10 years was associated with hyperbilirubinemia (OR = 3.83; 95% CI: 1.64-8.95), pancreatitis (OR = 3.72; 95% CI: 1.29-10.68), VTE (OR = 4.65; 95% CI: 1.96-11.02), and cumulative toxicity burden (OR = 3.28, 95% CI: 1.97-5.47); high-risk therapy with hypersensitivity (OR 2.25; 95% CI 1.25-4.05); and overweight with cumulative toxicity burden (OR = 1.76, 95% CI: 1.20-2.57). Eight unique toxicity profiles were identified. Older age, overweight, and treatment intensity contribute to pegaspargase-associated toxicities.
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