4.7 Review

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

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Humoral and cellular immune responses to recombinant herpes zoster vaccine in patients with chronic lymphocytic leukemia and monoclonal B cell lymphocytosis

Eli Muchtar et al.

Summary: This study investigated the immunogenicity of RZV in MBL/CLL patients and found that the antibody and T-cell responses to the vaccine were lower compared to historic controls, with only 29% of participants achieving combined responses. Hypogammaglobulinemia and BTKi therapy were associated with reduced T-cell responses. Strategies to improve vaccine response in MBL/CLL patients are needed to enhance protection against infections.

AMERICAN JOURNAL OF HEMATOLOGY (2022)

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Epstein-Barr virus positivity as a defining pathogenetic feature of Burkitt lymphoma subtypes

Lorenzo Leoncini

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Article Hematology

Epstein-Barr virus status of sporadic Burkitt lymphoma is associated with patient age and mutational features

Julia Richter et al.

Summary: Sporadic Burkitt lymphoma shows molecular heterogeneity across different age groups, with mutations commonly seen in pediatric BL such as ID3, TCF3, and CCND3 decreasing in adult patients. EBV-positive lymphomas are more frequent in adult patients and exhibit distinct pathogenic features compared to EBV-negative tumors.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

Review Oncology

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Summary: Hairy cell leukemia variant (HCL-V) is a rare and aggressive B cell lymphoproliferative disorder with distinct clinical and pathological features from classic hairy cell leukemia (HCL-C). It has a higher likelihood of being refractory to conventional purine analog therapies and leads to a poorer prognosis. While there is no specific genetic mutation diagnostic of HCL-V, genetic profiling has identified potential therapeutic targets and prognostic markers. Combination chemoimmunotherapies have shown the best results in HCL-V, but targeted therapies and CAR-T cell therapy are being explored for future advancements.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2022)

Article Hematology

Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS

Cho Mar Myint Wai et al.

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Geographic Variability of Nodular Lymphocyte-Predominant Hodgkin Lymphoma A Clinicopathologic Reappraisal in the Modern Era

Daniel Xia et al.

Summary: NLPHL differs from CHL in terms of clinicopathologic features and EBV association, showing few geographic differences. These findings have significant implications for the diagnosis, prognosis, and treatment of NLPHL patients in LMICs.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2022)

Article Hematology

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Michele Cavo et al.

Summary: In this study, we explored the impact of minimal residual disease (MRD) on relapsed/refractory multiple myeloma (RRMM) and transplant-ineligible newly diagnosed multiple myeloma (TIE NDMM). The results showed that achieving complete response or better (>= CR) and MRD negativity were associated with improved progression-free survival (PFS) in both RRMM and TIE NDMM patients, regardless of the type of therapy or disease setting.
Review Hematology

KSHV/HHV8-mediated hematologic diseases

Ethel Cesarman et al.

Summary: Kaposi sarcoma herpesvirus (KSHV), also known as human herpesvirus 8, is associated with various lymphoproliferative disorders. KSHV and Epstein-Barr virus (EBV) can infect and transform the same B cell, potentially leading to different diseases. Understanding KSHV biology and clinical features is crucial for targeted therapeutic interventions.
Article Pathology

Mutational landscape of marginal zone B-cell lymphomas of various origin: organotypic alterations and diagnostic potential for assignment of organ origin

Visar Vela et al.

Summary: This meta-analysis provides a concise summary of the genetic landscape of different types of MZL in various organs, showing the origin-specific distribution of distinct gene mutations, which may facilitate the identification of MZL origin and potential tailored treatment strategies.

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Article Hematology

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch

Michaela Novakova et al.

Summary: The study documented a BCP-ALL subtype with early switch to monocytic lineage and loss of B-cell immunophenotype, correlated with three genetic subtypes. The monocytic switch had significant impact on residual disease assessment and treatment outcomes.

HAEMATOLOGICA (2021)

Article Pathology

Cytogenetic complexity and heterogeneity in intravascular lymphoma

Kohei Fujikura et al.

Summary: Approximately half of IVLBCL cases exhibited a highly heterogeneous pattern of karyotypes with different clonal numerical and structural chromosome aberrations.

JOURNAL OF CLINICAL PATHOLOGY (2021)

Article Hematology

Mutational landscape of gray zone lymphoma

Clementine Sarkozy et al.

Summary: The mutational landscape of gray zone lymphoma (GZL) differs between cases with and without thymic niche involvement, showing distinct patterns related to apoptosis defects and BCL2/BCL6 rearrangements, respectively. Additionally, poly-EBV-L cases exhibit a unique mutational profile with STAT3 mutations and lower coding mutation load compared to EBV- GZL. These findings suggest common cell of origin and disease evolution among GZL with thymic presentation and related anterior mediastinal lymphomas.
Article Pathology

Lymph node involvement by enteropathy-like indolent NK-cell proliferation

Jean-Louis Dargent et al.

Summary: NKCE and LG are closely related lymphoproliferative disorders composed of mature and EBV-negative NK cells, mainly arising within the gastrointestinal tract but occasionally involving other sites. This case report describes a unique lymph node infiltration by such EBV-negative NK cell proliferation, exhibiting similar features to NKCE or LG, suggesting occasional lymph node involvement by similar indolent EBV-negative NK cell LPDs.

VIRCHOWS ARCHIV (2021)

Article Hematology

Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures

Michael Hallek et al.

Summary: Chronic lymphocytic leukemia is a common type of leukemia in elderly patients, diagnosed through blood tests and immunophenotyping. Treatment is determined based on disease activity and stage, with different genetic and biological markers providing prognostic information.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Pathology

New Clinicopathologic Scenarios of EBV+ Inflammatory Follicular Dendritic Cell Sarcoma Report of 9 Extrahepatosplenic Cases

Xiang-Nan Jiang et al.

Summary: EBV-positive inflammatory FDC sarcoma is a rare malignant neoplasm that occurs mainly in extrahepatosplenic anatomical sites, with an association with Epstein-Barr virus. These tumors typically occur near the aerodigestive tract and exhibit consistent histological features under the microscope. The patients have a median age of 58 years, with a female predominance over males.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

Article Hematology

Whole-genome landscape of adult T-cell leukemia/lymphoma

Yasunori Kogure et al.

Article Oncology

Standardization of 18F-FDG-PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma

Elena Zamagni et al.

Summary: This study analyzed the metabolic response of PET/CT scans in newly diagnosed transplantation-eligible patients with multiple myeloma, and found that FL and bone marrow FDG uptake lower than liver background could predict prolonged progression-free survival and overall survival, suggesting their value as standardized criteria for PET complete metabolic response in patients with MM.

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Article Immunology

The humoral immune response to high-dose influenza vaccine in persons with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)

Jennifer A. Whitaker et al.

Summary: Among patients with chronic lymphocytic leukemia (CLL) and monoclonal B cell lymphocytosis (MBL), the immunogenicity of high-dose influenza vaccine is lower compared to healthy adults, with MBL patients showing greater immunogenicity against influenza B compared to CLL patients.

VACCINE (2021)

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The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

Eileen M. Boyle et al.

Summary: The study found that smoldering myeloma (SMM) has fewer NRAS and FAM46C mutations, as well as fewer adverse translocations, when compared to newly diagnosed myeloma. KRAS mutations are associated with a shorter time to progression. Changes in clonal structure, branching evolutionary patterns, and other genetic mechanisms may underlie the transition from SMM to MM, providing insights for early intervention strategies.

NATURE COMMUNICATIONS (2021)

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Next generation sequencing of breast implant-associated anaplastic large cell lymphomas reveals a novel STAT3-JAK2 fusion among other activating genetic alterations within the JAK-STAT pathway

Andres E. Quesada et al.

Summary: Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a distinct subtype characterized by genetic absence of fusions and frequent activation of the JAK-STAT3 pathway. Genetic profiling of BIA-ALCL cases revealed activation of the STAT3-JAK2 fusion, providing further insight into potential targeted therapy options for advanced cases.

BREAST JOURNAL (2021)

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Clinical, immunophenotypic and genomic findings of NK lymphoblastic leukemia: a study from the Bone Marrow Pathology Group

Olga K. Weinberg et al.

Summary: NK-LL is a rare type of acute leukemia with distinct clinical presentation, immunophenotypic, and molecular characteristics compared to other types of acute leukemias. The study found that NK-LL patients are typically younger with higher white blood cell and platelet counts, and exhibit differences in certain immunophenotypic markers and gene mutations compared to other types of acute leukemias.

MODERN PATHOLOGY (2021)

Article Medicine, General & Internal

Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis

Midori Filiz Nishimura et al.

Summary: HV-UCD is a disease often asymptomatic and incidentally discovered on imaging tests. This study reviewed detailed clinical and pathological findings of 38 cases, with the most common site involved being the abdominal cavity. The pathological features observed included thick hyalinized collagen fibers and multinucleated giant cells in some cases.

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Characteristics and outcomes of KSHV-associated multicentric Castleman disease with or without other KSHV diseases

Ramya Ramaswami et al.

Summary: KSHV-MCD is a relapsing and remitting disorder common in PLWH, characterized by severe inflammation and concurrent KSHV-associated diseases. Treatment options include AZT/VGC, rituximab, and R-Dox, with participants receiving R-Dox and maintenance AZT/VGC having the highest 5-year progression-free survival (89%).

BLOOD ADVANCES (2021)

Article Pathology

High-grade Follicular Lymphomas Exhibit Clinicopathologic, Cytogenetic, and Molecular Diversity Extending Beyond Grades 3A and 3B

Camille Laurent et al.

Summary: This study investigated the clinicopathologic diversity of grade 3 follicular lymphoma (FL3) and found that some cases did not strictly fit WHO criteria for either FL3A or FL3B, being classified as unconventional high-grade FL (FL3U). FL3U cases displayed worse outcomes compared to FL1-2 patients, suggesting that high-grade FLs encompass a heterogeneous spectrum of tumors with variable morphology and genomic alterations. The distinction of FL3U may be useful for a better comprehension of high-grade FLs and for designing clinical trials.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

Article Oncology

Cutaneous T-cell lymphomas-An update 2021

Werner Kempf et al.

Summary: CTCL, including MF and cutaneous CD30+ lymphoproliferative disorders, requires clinical-pathological correlation for diagnosis. Treatment is stage-adapted with options like UV-light therapies, corticosteroids, and targeted therapies. Novel therapies such as mogamulizumab, brentuximab vedotin, and histone deacetylase inhibitors have been introduced for better management.

HEMATOLOGICAL ONCOLOGY (2021)

Article Oncology

Thyroid MALT lymphoma: self-harm to gain potential T-cell help

Fangtian Wu et al.

Summary: The study found that genetic changes in CD274 and TNFRSF14 in thyroid MALT lymphoma are significantly associated with Hashimoto's thyroiditis. Inactivation of CD274/TNFRSF14 may disrupt the interaction between malignant B cells and T cells, promoting co-stimulations and impairing peripheral tolerance.

LEUKEMIA (2021)

Review Pathology

Counting mitoses: SI(ze) matters!

Ian A. Cree et al.

Summary: Mitoses in cancer diagnosis are often assessed by counting per square millimeter, but the variation in microscope fields, especially in digital pathology systems, can lead to errors. Standardized international units should be used to ensure accuracy in mitotic count.

MODERN PATHOLOGY (2021)

Review Genetics & Heredity

T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness

Valentina Bardelli et al.

Summary: T-ALL is an immature lymphoid tumor affecting bone marrow, lymphoid organs, etc. It is a heterogeneous disease caused by multiple genetic abnormalities.
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Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia

Ilaria Iacobucci et al.

Summary: Acute lymphoblastic leukemia (ALL) has achieved cure rates exceeding 90% in children, but remains a leading cause of cancer-related death in the young. Next generation sequencing has led to significant advances in understanding leukemogenesis and the development of novel therapeutic approaches, including mutation-specific and mutation-agnostic treatments.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Oncology

ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas

Sergio Pina-Oviedo et al.

Summary: Anaplastic large cell lymphoma (ALCL) is a subtype of CD30+ large T-cell lymphoma. It is divided into ALK+ and ALK- based on the expression of anaplastic lymphoma kinase (ALK), with different clinical and prognostic outcomes. Recent studies have identified recurrent genetic alterations in ALK- ALCL, some of which have prognostic value and may lead to potential targeted therapies for this subtype of TCL.

CANCERS (2021)

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Striking Association of Lymphoid Enhancing Factor (LEF1) Overexpression and DUSP22 Rearrangements in Anaplastic Large Cell Lymphoma

Aishwarya Ravindran et al.

Summary: Anaplastic large cell lymphomas (ALCLs) are classified into ALK-positive and ALK-negative, with ALK-negative cases composed of DUSP22-rearranged, TP63-rearranged, and triple-negative cases. In ALCL, LEF1 expression is significantly higher in DUSP22-rearranged cases, indicating a distinct clinicopathologic subset. The strong and uniform LEF1 expression in ALCL has high predictive value for DUSP22 rearrangement, although it may not be involved in the Wnt/beta-catenin pathway.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

Article Pathology

A Diagnostic Approach to the Identification of Burkitt-like Lymphoma With 11q Aberration in Aggressive B-Cell Lymphomas

Heike Horn et al.

Summary: Analysis of 11q status is recommended for MYC-negative high-grade lymphomas with features of Burkitt lymphoma, especially showing BCL2 negativity and a conspicuous coarse apoptotic debris in starry sky macrophages.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

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The immune contexture of primary central nervous system diffuse large B cell lymphoma associates with patient survival and specific cell signaling

Melissa Alame et al.

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Flow cytometric features of incidental indolent T lymphoblastic proliferations

Jonathan R. Fromm et al.

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An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract

Rahul Krishnan et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2020)

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The TEMPI syndrome

David B. Sykes et al.

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Steven P. Treon et al.

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Epstein - Barr virus positive T and NK-cell lymphoproliferations: Morphological features and differential diagnosis

Ivonne A. Montes-Mojarro et al.

SEMINARS IN DIAGNOSTIC PATHOLOGY (2020)

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Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia

Antonella Teramo et al.

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Genomic and Immunophenotypic Landscape of Aggressive NK-Cell Leukemia

Siba El Hussein et al.

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Detection of cryptic CCND1 rearrangements in mantle cell lymphoma by next generation sequencing

Katarzyna Polonis et al.

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Disease Progression in a Patient With Indolent T-Cell Lymphoproliferative Disease of the Gastrointestinal Tract

Anamarija M. Perry et al.

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Letter Hematology

Identification of high-risk DUSP22-rearranged ALK-negative anaplastic large cell lymphoma

Greg Hapgood et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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p53 and β-Catenin Expression Predict Poorer Prognosis in Patients With Anaplastic Large-Cell Lymphoma

Aida Ibricevic Richardson et al.

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Chronic lymphocytic leukaemia: from genetics to treatment

Francesc Bosch et al.

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Recurrent somatic JAK3 mutations in NK-cell enteropathy

Wenbin Xiao et al.

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The whole-genome landscape of Burkitt lymphoma subtypes

Razvan I. Panea et al.

Review Hematology

Recent advances in the diagnosis and treatment of natural killer/T-cell lymphomas

Eric Tse et al.

EXPERT REVIEW OF HEMATOLOGY (2019)

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Hydroa vacciniforme-like lymphoproliferative disorder: Clinicopathologic study of 41 cases

Yanghe Liu et al.

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PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

Zhaohui Gu et al.

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Stratification of Follicular Lymphoma Time for a Paradigm Shift?

Steven H. Kroft

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Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL)

Srinivasa R. Sanikommu et al.

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Recurrent Cytogenetic Abnormalities in Intravascular Large B-Cell Lymphoma

Matthew M. Klairmont et al.

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R. Favre et al.

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Panel Sequencing Shows Recurrent Genetic FAS Alterations in Primary Cutaneous Marginal Zone Lymphoma

Katja Maurus et al.

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Coordinated repression of BIM and PUMA by Epstein-Barr virus latent genes maintains the survival of Burkitt lymphoma cells

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The exomic landscape of t(14;18)-negative diffuse follicular lymphoma with 1p36 deletion

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Cutaneous intravascular natural killer/T cell lymphoma with peculiar immunophenotype

Victoria Alegria-Landa et al.

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Enrico Tiacci et al.

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Clonal B-cell lymphocytosis of marginal zone origin

Aliki Xochelli et al.

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Prognostic Factors of Hepatosplenic T-cell Lymphoma Clinicopathologic Study of 28 Cases

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The genetics of nodal marginal zone lymphoma

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Ki Sun Jung et al.

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PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome

Margaretha G. M. Roemer et al.

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Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements

Rebecca L. King et al.

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TdT+ T-Lymphoblastic Proliferation in Castleman Disease

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Cutaneous Intravascular Natural Killer-Cell Lymphoma A Case Report and Review of the Literature

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New clues to the molecular pathogenesis of Burkitt lymphoma revealed through next-generation sequencing

Adrienne Greenough et al.

CURRENT OPINION IN HEMATOLOGY (2014)

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Breast Implant-Associated Anaplastic Large-Cell Lymphoma: Long-Term Follow-Up of 60 Patients

Roberto N. Miranda et al.

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Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells

Meryem Jarjour et al.

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Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

Mamiko Sakata-Yanagimoto et al.

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Kikuchi-Fujimoto Disease Retrospective Study of 91 Cases and Review of the Literature

Guillaume Dumas et al.

MEDICINE (2014)

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KSHV/HHV8-negative Effusion-based Lymphoma, a Distinct Entity Associated With Fluid Overload States

Serge Alexanian et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2013)

Review Hematology

Cold agglutinin disease

Paul L. Swiecicki et al.

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EBV-Positive T/NK-Cell Lymphoproliferative Disease of Childhood

Mineui Hong et al.

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MYD88 L265P Somatic Mutation in Waldenstrom's Macroglobulinemia

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The TEMPI Syndrome - A Novel Multisystem Disease

David B. Sykes et al.

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The complex landscape of genetic alterations in mantle cell lymphoma

Cristina Royo et al.

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Article Medical Laboratory Technology

Different Biology and Clinical Outcome According to the Absolute Numbers of Clonal B-Cells in Monoclonal B-Cell Lymphocytosis (MBL)

Andy C. Rawstron et al.

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Follicular dendritic cell sarcoma with immature T-cell proliferation

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HUMAN PATHOLOGY (2010)

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Indolent T-lymphoblastic proliferation in Castleman lymphadenopathy

You-Wen Qian et al.

LEUKEMIA & LYMPHOMA (2009)

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'Precursors' of classical Hodgkin lymphoma in samples of angioimmunoblastic T-cell lymphoma

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Hairy cell leukemia: Current concepts

Timothy Cannon et al.

CANCER INVESTIGATION (2008)

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c-Maf expression in angioimmunoblastic T-cell lymphoma

Yoshiko Idate Murakami et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2007)

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Differential diagnosis in chronic lymphocytic leukaemia

Estella Matutes

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2007)

Letter Dermatology

Cutaneous mucinous angiomatosis as a presenting sign of bone plasmacytoma: A new case of (A)ESOP syndrome

Franco Rongioletti et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2006)

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G-banding and molecular cytogenetic analyses of marginal zone lymphoma

HV Aamot et al.

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Diagnostic criteria for monoclonal B-cell lymphocytosis

GE Marti et al.

BRITISH JOURNAL OF HAEMATOLOGY (2005)

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KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma

A Chadburn et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2004)

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The variant form of hairy-cell leukaemia

E Matutes et al.

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K van Nierop et al.

SEMINARS IN IMMUNOLOGY (2002)