☆ 4.7 Review

Circulating tumor DNA in B-cell lymphoma: technical advances, clinical applications, and perspectives for translational research

LEUKEMIA (2022)

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Article Hematology

Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma

Leo Meriranta et al.

Summary: Liquid biopsy has important clinical significance in high-risk DLBCL patients, as it can reveal hidden clinical and biological heterogeneity, predict the risk of relapse and death, and provide molecular information for treatment decisions.

BLOOD (2022)

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Article Medicine, General & Internal

Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma

F. L. Locke et al.

Summary: This international phase 3 trial showed that axicabtagene ciloleucel therapy significantly improved event-free survival and response in patients with early relapsed or refractory large B-cell lymphoma compared to standard care, despite the expected high-grade toxic effects.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Hematology

Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma

Rahul Lakhotia et al.

Summary: This study analyzed the dynamics of circulating tumor DNA (ctDNA) in patients with mantle cell lymphoma (MCL) following induction therapy. The results showed that patients with negative ctDNA after induction had longer survival, suggesting the potential of ctDNA as a prognostic biomarker. This supports further investigation into the use of ctDNA for response-adapted strategies in MCL.

BLOOD ADVANCES (2022)

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Editorial Material Hematology

The many facets of liquid biopsies in lymphoma

David M. Kurtz

Summary: The study investigates circulating tumor DNA analysis in patients with large B-cell lymphomas undergoing first-line therapy, providing insights into the quantitative measurements, dynamic changes, and mutational genotypes of tumor-derived cell-free DNA during and after treatment.

BLOOD (2022)

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Article Biotechnology & Applied Microbiology

Inferring gene expression from cell-free DNA fragmentation profiles

Mohammad Shahrokh Esfahani et al.

Summary: EPIC-seq is a method that predicts gene expression levels at individual genes from cfDNA. We demonstrate the potential of EPIC-seq in cancer subtype classification and prediction of clinical response.

NATURE BIOTECHNOLOGY (2022)

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Article Hematology

Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas

Sabela Bobillo et al.

Summary: This study shows that CSF ctDNA can better detect CNS lesions and even detect residual disease after treatment. Additionally, CSF ctDNA can predict CNS relapse in CNS and systemic lymphomas.

HAEMATOLOGICA (2021)

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Article Hematology

Targeted genotyping of circulating tumor DNA for classical Hodgkin lymphoma monitoring: a prospective study

Vincent Camus et al.

Summary: The study demonstrates the significance of ctDNA analysis as a liquid biopsy and minimal residual disease tool in the management of cHL patients. By using a targeted NGS panel for fast analysis and monitoring the changes in ctDNA after chemotherapy, it helps to assess early treatment response and genetic features of cHL.

HAEMATOLOGICA (2021)

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Article Hematology

Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma

Kazuyuki Shimada et al.

Summary: IVLBCL is a unique type of extranodal lymphoma characterized by selective growth of tumor cells in small vessels without lymphadenopathy. Whole-exome sequencing revealed genetic features of activated B-cell-type DLBCL in IVLBCL, and identified rearrangements of PD-L1/PD-L2 and immune evasion mechanisms as potential therapeutic targets.

BLOOD (2021)

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Article Hematology

Profiling of Circulating Tumor DNA for Noninvasive Disease Detection, Risk Stratification, and MRD Monitoring in Patients with CNS Lymphoma

Jurik Andreas Mutter et al.

BLOOD (2021)

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Meeting Abstract Hematology

A Prospective Study of Clonal Evolution in Follicular Lymphoma: Circulating Tumor DNA Correlates with Overall Tumor Burden and Fluctuates over Time without Therapy

Allison Distler et al.

BLOOD (2021)

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Meeting Abstract Hematology

A Prospective Multicenter Study of Minimal Residual Disease Assessment Using a Next-Generation Immunosequencing Assay and CT Monitoring for Surveillance after Frontline Treatment in Diffuse Large B-Cell Lymphoma

Anita Kumar et al.

BLOOD (2021)

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Review Hematology

Circulating tumour DNA in B-cell lymphomas: current state and future prospects

Rahul Lakhotia et al.

Summary: Circulating tumor DNA (ctDNA) is a versatile analyte and emerging biomarker for lymphoid malignancies, providing a minimally invasive method to monitor treatment effectiveness and correlate with clinical outcomes in B-cell lymphomas. Standardization of analytical techniques and prospective validation within clinical studies are necessary for ctDNA to reach its full potential as a decision-making tool in oncology.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Hematology

MYD88 L265P mutation and interleukin-10 detection in cerebrospinal fluid are highly specific discriminating markers in patients with primary central nervous system lymphoma: results from a prospective study

Andres J. M. Ferreri et al.

Summary: This study found that high levels of mut-MYD88 and IL-10 in the CSF of patients with PCNSL reflect the MYD88 mutational status and expression of this IL in PCNSL tissue, showing very high sensitivity and specificity for detecting PCNSL at initial diagnosis and relapse. These biomarkers could have implications for patients with lesions unsuitable for biopsy.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

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Article Oncology

ROBUST: A Phase III Study of Lenalidomide Plus R-CHOP Versus Placebo Plus R-CHOP in Previously Untreated Patients With ABC-Type Diffuse Large B-Cell Lymphoma

Grzegorz S. Nowakowski et al.

Summary: The ROBUST study aimed to compare the efficacy of lenalidomide plus R-CHOP with placebo/R-CHOP in previously untreated ABC-type DLBCL. While the primary end point of progression-free survival (PFS) was not met in all patients, there were trends favoring R2-CHOP over placebo/R-CHOP in patients with higher-risk disease. The safety profile of R2-CHOP was consistent with individual treatments with no new safety signals.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Hematology

A rapid genotyping panel for detection of primary central nervous system lymphoma

Mihir Gupta et al.

Summary: Diagnosing PCNSL often requires neurosurgical biopsy due to low yield of CSF studies. A multiplexed genotyping assay was designed to facilitate rapid and accurate diagnosis of PCNSL. This targeted genotyping approach helps reduce diagnostic and treatment delays in PCNSL.

BLOOD (2021)

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Article Oncology

Short Diagnosis-to-Treatment Interval Is Associated With Higher Circulating Tumor DNA Levels in Diffuse Large B-Cell Lymphoma

Stefan Alig et al.

Summary: The study found relationships between pretreatment ctDNA levels and DTI, tumor burden, and other conventional risk factors in patients with DLBCL, highlighting the utility of pretreatment ctDNA levels in addressing selection biases in prospective clinical trials.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Review Oncology

Diffuse large B-cell lymphoma: new targets and novel therapies

Bruce D. Cheson et al.

Summary: Newer, more effective and non-cytotoxic therapies are needed for patients with DLBCL and other B-cell malignancies. Approved treatments include various combinations of drugs, CAR-T cell products, and ongoing development of other therapies. Combinations of targeted therapies are expected to further improve the outcomes for patients.

BLOOD CANCER JOURNAL (2021)

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Article Hematology

DETERMINANTS OF RESISTANCE TO ENGINEERED T‐CELL THERAPIES TARGETING CD19 IN LYMPHOMA

B Sworder et al.

HEMATOLOGICAL ONCOLOGY (2021)

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Article Hematology

NONINVASIVE DETECTION, CLASSIFICATION, AND RISK STRATIFICATION OF PRIMARY CNS LYMPHOMAS BY CTDNA PROFILING

J. A. Mutter et al.

HEMATOLOGICAL ONCOLOGY (2021)

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Article Hematology

PHASED VARIANTS IMPROVE DLBCL MINIMAL RESIDUAL DISEASE DETECTION AT THE END OF THERAPY

D. M Kurtz et al.

HEMATOLOGICAL ONCOLOGY (2021)

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Article Oncology

Monitoring of Circulating Tumor DNA Improves Early Relapse Detection After Axicabtagene Ciloleucel Infusion in Large B-Cell Lymphoma: Results of a Prospective Multi-Institutional Trial

Matthew J. Frank et al.

Summary: This study demonstrated the prognostic value of circulating tumor DNA (ctDNA) in predicting outcomes of large B-cell lymphoma patients undergoing axicabtagene ciloleucel (axi-cel) treatment. Higher baseline ctDNA concentrations were associated with progression post-treatment and development of toxicities. Additionally, patients with undetectable ctDNA 1 week after axi-cel infusion had higher rates of durable response compared to those with detectable ctDNA.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Enhanced detection of minimal residual disease by targeted sequencing of phased variants in circulating tumor DNA

David M. Kurtz et al.

Summary: PhasED-seq improves the sensitivity of ctDNA detection by using multiple somatic mutations in individual DNA fragments, outperforming previous methods with better limits of detection in the ppm range. In patients with B cell lymphomas, PhasED-seq can detect more cases of ctDNA positivity associated with worse outcomes. The method is also applicable to solid tumors.

NATURE BIOTECHNOLOGY (2021)

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Review Oncology

Liquid Biopsy and Other Non-Invasive Diagnostic Measures in PCNSL

Alexander Baraniskin et al.

Summary: Primary central nervous system lymphoma (PCNSL) is a rare and highly aggressive form of non-Hodgkin lymphoma that requires a high level of suspicion for diagnosis due to its variable clinical presentation. While stereotactic brain biopsy remains the gold standard for diagnosis, potential procedural risks and delays in treatment initiation need to be considered. Novel diagnostic approaches, such as mutation analyses in circulating tumor DNA and determination of microRNAs and cytokine levels in body fluids, are being investigated to improve PCNSL diagnosis.

CANCERS (2021)

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Article Hematology

Detection of clonotypic DNA in the cerebrospinal fluid as a marker of central nervous system invasion in lymphoma

Adam J. Olszewski et al.

Summary: The study found that the NGS-MRD assay can aid in the diagnosis of suspected parenchymal brain recurrence in aggressive lymphoma, and is also important for predicting CNS recurrence in patients with high-risk newly diagnosed B-cell lymphomas.

BLOOD ADVANCES (2021)

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Article Oncology

Mutational Landscape and Tumor Burden Assessed by Cell-free DNA in Diffuse Large B-Cell Lymphoma in a Population-Based Study

Alfredo Rivas-Delgado et al.

Summary: The study analyzed the utility of cfDNA in DLBCL patients to determine mutational profile and tumor burden. It found that higher levels of ctDNA were associated with clinical parameters and treatment response in DLBCL patients.

CLINICAL CANCER RESEARCH (2021)

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Article Oncology

MRD response in relapsed/refractory FL after obinutuzumab plus bendamustine or bendamustine alone in the GADOLIN trial

Christiane Pott et al.

LEUKEMIA (2020)

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Article Oncology

Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma

Ann-Kathrin Desch et al.

LEUKEMIA (2020)

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Editorial Material Oncology

The development of liquid biopsy for research and clinical practice in lymphomas: Report of the 15-ICML workshop on ctDNA

Davide Rossi et al.

HEMATOLOGICAL ONCOLOGY (2020)

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Article Genetics & Heredity

Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors

Christopher G. Smith et al.

GENOME MEDICINE (2020)

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Article Multidisciplinary Sciences

Integrating genomic features for non-invasive early lung cancer detection

Jacob J. Chabon et al.

NATURE (2020)

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Article Genetics & Heredity

Quantitative Analysis and Monitoring of EZH2 Mutations Using Liquid Biopsy in Follicular Lymphoma

Akos Nagy et al.

GENES (2020)

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Article Medicine, General & Internal

Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management

Julius Wehrle et al.

DIAGNOSTICS (2020)

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Genetic and evolutionary patterns of treatment resistance in relapsed B-cell lymphoma

Christopher K. Rushton et al.

BLOOD ADVANCES (2020)

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Article Biochemistry & Molecular Biology

Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes

Pier Vitale Nuzzo et al.

NATURE MEDICINE (2020)

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Article Oncology

Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial

Franck Morschhauser et al.

LANCET ONCOLOGY (2020)

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Review Biochemistry & Molecular Biology

Liquid biopsy approaches for pleural effusion in lung cancer patients

Gayathri Baburaj et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Review Oncology

Liquid biopsy in lymphoma: Molecular methods and clinical applications

Melita Cirillo et al.

CANCER TREATMENT REVIEWS (2020)

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Article Hematology

The role of PET in first-line treatment of Hodgkin lymphoma

Judith Trotman et al.

Lancet Haematology (2020)

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Meeting Abstract Hematology

Prognostic Value of Circulating Tumor DNA (ctDNA) in Autologous Stem Cell Graft and Post-Transplant Plasma Samples Among Patients with Diffuse Large B-Cell Lymphoma

Reid W. Merryman et al.

BLOOD (2020)

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Molecular tumor analysis and liquid biopsy: a feasibility investigation analyzing circulating tumor DNA in patients with central nervous system lymphomas

Anne-Katrin Hickmann et al.

BMC CANCER (2019)

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Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma

Anas Younes et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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CELL (2019)

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Comparison of circulating tumor DNA between body fluids in patients with primary central nervous system lymphoma

Jun Watanabe et al.

LEUKEMIA & LYMPHOMA (2019)

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High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

Pedram Razavi et al.

NATURE MEDICINE (2019)

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Article Hematology

Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma

Christian Grommes et al.

BLOOD (2019)

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Letter Hematology

MYD88 p.(L265P) detection on cell-free DNA in liquid biopsies of patients with primary central nervous system lymphoma

Laura S. Hiemcke-Jiwa et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

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Meeting Abstract Hematology

Minimal Residual Disease (MRD) Assessment in the ECOG1411 Randomized Phase 2 Trial of Front-Line Bendamustine-Rituximab (BR)-Based Induction Followed By Rituximab (R) ± Lenalidomide (L) Consolidation for Mantle Cell Lymphoma (MCL)

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BLOOD (2019)

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Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal et al.

NATURE MEDICINE (2019)

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Detection and Surveillance of Bladder Cancer Using Urine Tumor DNA

Jonathan C. Dudley et al.

CANCER DISCOVERY (2019)

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Comparison of Roche Cell-Free DNA collection Tubes® to Streck Cell-Free DNA BCT®s for sample stability using healthy volunteers

Sarah Parackal et al.

PRACTICAL LABORATORY MEDICINE (2019)

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The use of droplet digital PCR in liquid biopsies: A highly sensitive technique for MYD88 p.(L265P) detection in cerebrospinal fluid

Laura S. Hiemcke-Jiwa et al.

HEMATOLOGICAL ONCOLOGY (2018)

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Circulating tumor DNA reveals genetics, clonal evolution, and residual disease in classical Hodgkin lymphoma

Valeria Spina et al.

BLOOD (2018)

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Ibrutinib resistance in mantle cell lymphoma: clinical, molecular and treatment aspects

Oshrat Hershkovitz-Rokah et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

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Letter Hematology

Liquid biopsy for the identification of intravascular large B-cell lymphoma

Yasuhito Suehara et al.

HAEMATOLOGICA (2018)

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Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL): A Multicenter, Randomized Phase III Trial

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JOURNAL OF CLINICAL ONCOLOGY (2018)

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NATURE MEDICINE (2018)

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NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

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NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Medicine, General & Internal

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

Constantine S. Tam et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Letter Hematology

Liquid biopsy for the identification of intravascular large B-cell lymphoma

Yasuhito Suehara et al.

HAEMATOLOGICA (2018)

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Article Oncology

Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma

David M. Kurtz et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Non-invasive monitoring of diffuse large B-cell lymphoma by cell-free DNA high-throughput targeted sequencing: analysis of a prospective cohort

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BLOOD CANCER JOURNAL (2018)

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Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma

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CANCER SCIENCE (2018)

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Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma

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BLOOD ADVANCES (2018)

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Early Treatment Intensification With R-ICE And 90Y-Ibritumomab Tiuxetan (Zevalin)-BEAM Stem Cell Transplantation In Patients With High Risk Diffuse Large B-Cell Lymphoma Patients And Positive Interim PET After 4 Cycles Of R-CHOP-14

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HAEMATOLOGICA (2017)

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Article Hematology

Early Treatment Intensification With R-ICE And 90Y-Ibritumomab Tiuxetan (Zevalin)-BEAM Stem Cell Transplantation In Patients With High Risk Diffuse Large B-Cell Lymphoma Patients And Positive Interim PET After 4 Cycles Of R-CHOP-14

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HAEMATOLOGICA (2017)

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Randomized Phase II Study of R-CHOP With or Without Bortezomib in Previously Untreated Patients With Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma

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JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Oncology

Rituximab-dose-dense chemotherapy with or without high-dose chemotherapy plus autologous stem-cell transplantation in high-risk diffuse large B-cell lymphoma (DLCL04): final results of a multicentre, open-label, randomised, controlled, phase 3 study

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Article Oncology

The prognostic value of clonal heterogeneity and quantitative assessment of plasma circulating clonal IG-VDJ sequences at diagnosis in patients with follicular lymphoma

Clementine Sarkozy et al.

ONCOTARGET (2017)

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Article Oncology

Non-invasive detection of somatic mutations using nextgeneration sequencing in primary central nervous system lymphoma

Maxime Fontanilles et al.

ONCOTARGET (2017)

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Article Hematology

FDG-PET-driven consolidation strategy in diffuse large B-cell lymphoma: final results of a randomized phase 2 study

R. -O. Casasnovas et al.

BLOOD (2017)

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Review Hematology

High-throughput sequencing for noninvasive disease detection in hematologic malignancies

Florian Scherer et al.

BLOOD (2017)

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Article Hematology

Diffuse large B-cell lymphoma genotyping on the liquid biopsy

Davide Rossi et al.

BLOOD (2017)

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Review Oncology

Liquid biopsies come of age: towards implementation of circulating tumour DNA

Jonathan C. M. Wan et al.

NATURE REVIEWS CANCER (2017)

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Article Oncology

Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation

Florian Scherer et al.

LEUKEMIA & LYMPHOMA (2016)

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Article Hematology

Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma

Sarit E. Assouline et al.

BLOOD (2016)

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Article Hematology

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

Vincent Camus et al.

HAEMATOLOGICA (2016)

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Article Biotechnology & Applied Microbiology

Integrated digital error suppression for improved detection of circulating tumor DNA

Aaron M. Newman et al.

NATURE BIOTECHNOLOGY (2016)

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Article Cell Biology

Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA

Florian Scherer et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations

Chenglin Wu et al.

ONCOTARGET (2016)

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Article Oncology

Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones

Thomas Melchardt et al.

ONCOTARGET (2016)

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Article Medicine, General & Internal

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

Robert Kridel et al.

PLOS MEDICINE (2016)

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Article Hematology

Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma

Vincent Camus et al.

HAEMATOLOGICA (2016)

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Meeting Abstract Hematology

Noninvasive Detection of Ibrutinib Resistance in Non-Hodgkin Lymphoma Using Cell-Free DNA

Florian Scherer et al.

BLOOD (2016)

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Article Hematology

Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing

David M. Kurtz et al.

BLOOD (2015)

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Article Hematology

Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404)

Lode J. Swinnen et al.

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Article Oncology

Cost-Effectiveness Analysis of Routine Surveillance Imaging of Patients With Diffuse Large B-Cell Lymphoma in First Remission

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Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study

Mark Roschewski et al.

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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma

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NATURE MEDICINE (2015)

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BLOOD (2014)

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Utility of Routine Post-Therapy Surveillance Imaging in Diffuse Large B-Cell Lymphoma

Carrie A. Thompson et al.

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Article Biochemistry & Molecular Biology

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Aaron M. Newman et al.

NATURE MEDICINE (2014)

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Scott R. Kennedy et al.

NATURE PROTOCOLS (2014)

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Article Medicine, General & Internal

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Siddhartha Jaiswal et al.

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Laura Pasqualucci et al.

CELL REPORTS (2014)

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Review Clinical Neurology

Stereotactic biopsy of brainstem lesions: Techniques, efficacy, safety, and disease variation between adults and children: A single institutional series and review

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Utility of Flow Cytometry of Cerebrospinal Fluid as a Screening Tool in the Diagnosis of Central Nervous System Lymphoma

Meredith Pittman et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2013)

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Article Medicine, General & Internal

Autologous Transplantation as Consolidation for Aggressive Non-Hodgkin's Lymphoma

Patrick J. Stiff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Review Medicine, Research & Experimental

Pathogenesis of follicular lymphoma

Robert Kridel et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

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Article Multidisciplinary Sciences

Detection of ultra-rare mutations by next-generation sequencing

Michael W. Schmitt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Hematology

Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium

Gilles Salles et al.

BLOOD (2011)

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Review Oncology

Transformation of Indolent B-Cell Lymphomas

Silvia Montoto et al.

JOURNAL OF CLINICAL ONCOLOGY (2011)

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Article Oncology

Risk-Adapted Dose-Dense Immunochemotherapy Determined by Interim FDG-PET in Advanced-Stage Diffuse Large B-Cell Lymphoma

Craig H. Moskowitz et al.

JOURNAL OF CLINICAL ONCOLOGY (2010)

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Review Hematology

A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma

Eva Hoster et al.

BLOOD (2008)

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Article Medicine, General & Internal

Stromal Gene Signatures in Large-B-Cell Lymphomas

G. Lenz et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Oncology

Definition, diagnosis, and management of intravascular large B-Cell lymphoma: Proposals and perspectives from an international consensus meeting

Maurilio Ponzoni et al.

JOURNAL OF CLINICAL ONCOLOGY (2007)

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Article Clinical Neurology

Stereotactic computed tomography-guided brain biopsy: diagnostic yield based on a series of 170 patients

MP Ferreira et al.

SURGICAL NEUROLOGY (2006)

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Article Hematology

Follicular lymphoma international prognostic index

P Solal-Céligny et al.

BLOOD (2004)

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Article Hematology

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

CP Hans et al.

BLOOD (2004)

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Article Hematology

Age-adjusted International Prognostic Index predicts autologous stem cell transplantation outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma

PA Hamlin et al.

BLOOD (2003)

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Article Medicine, General & Internal

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma

A Rosenwald et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Article Multidisciplinary Sciences

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

L Pasqualucci et al.

NATURE (2001)

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Article Multidisciplinary Sciences

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

AA Alizadeh et al.

NATURE (2000)

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