4.6 Article

a-Synuclein Interaction with Lipid Bilayer Discs

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

The very small angle neutron scattering instrument at the National Institute of Standards and Technology

John Barker et al.

Summary: The very small angle neutron scattering diffractometer at the National Institute of Standards and Technology offers a wide measurement range and flexible collimation options to meet various experimental needs. By using multiple techniques in combination, the instrument balances high resolution with high beam intensity, providing more choices for experiments.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2022)

Review Biochemistry & Molecular Biology

Interactions of α-synuclein oligomers with lipid membranes

Greta Musteikyte et al.

Summary: Parkinson's disease is an incurable neurodegenerative disorder characterized by the formation of Lewy bodies. Oligomeric forms of the protein alpha-synuclein interacting with lipid membranes are considered the main pathogenic species. Understanding the structural and biophysical features of these oligomers and their interactions with membranes is crucial for deciphering the etiology of Parkinson's disease and its toxicity in vivo.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2021)

Article Chemistry, Multidisciplinary

Interaction of Dopamine with Zwitterionic DMPC and Anionic DMPS Multilamellar Vesicle Membranes

Anand Kumar Sahu et al.

Summary: This report investigates the interaction of dopamine with different types of membranes using DSC and intrinsic fluorescence techniques. The results indicate a strong specific interaction between dopamine and the anionic DMPS membrane, while a weaker interaction is observed with the zwitterionic DMPC membrane.

LANGMUIR (2021)

Article Chemistry, Physical

Membrane Remodeling and Stimulation of Aggregation Following α-Synuclein Adsorption to Phosphotidylserine Vesicles

Brandon M. Hoover et al.

Summary: The interaction of alpha-synuclein with DLPS vesicles can induce extensive vesicle disruption and membrane remodeling, promoting protein aggregation, whereas DOPS vesicles do not show this effect. The adsorption of alpha-synuclein to DLPS vesicles leads to vesicle elongation and redistribution of protein to regions of higher curvature, driving the aggregation process. These findings highlight the critical role of bilayer stability in the membrane response to alpha-synuclein adsorption and aggregation stimulation.

JOURNAL OF PHYSICAL CHEMISTRY B (2021)

Article Cell Biology

Transient Lipid-Protein Structures and Selective Ganglioside Uptake During α-Synuclein-Lipid Co-aggregation

Ricardo Gaspar et al.

Summary: The study reveals the co-association of alpha-synuclein and ganglioside lipids, showing the presence of non-vesicular objects during the aggregation process that evolve into thin fibrillar structures heavily decorated with small vesicles. The selective uptake of GM1 into the fibrillar aggregates and removal of GM1-rich objects from the solution is also observed.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Cooperativity of α-Synuclein Binding to Lipid Membranes

Katarzyna Makasewicz et al.

Summary: Cooperative binding is a crucial feature in metabolic pathways, signaling, and transport processes, allowing for tight regulation over a narrow concentration range. The study shows strong positive cooperativity of alpha-synuclein binding to phospholipid membranes, indicating that the protein has a higher affinity for a membrane where there is already bound protein, compared to a bare membrane.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Self-Assembly in GangliosidePhospholipid Systems: The Co-Existence of Vesicles, Micelles, and Discs

Enamul Haque Mojumdar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein

Jonas K. Hannestad et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Chemistry, Physical

Effect of gangliosides on structure and integrity of polyethylene glycol (PEG)-stabilized liposomes

Philipp Grad et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2020)

Article Chemistry, Multidisciplinary

Shape and Phase Transitions in a PEGylated Phospholipid System

Lauri Viitala et al.

LANGMUIR (2019)

Review Neurosciences

α-Synuclein: A Multifunctional Player in Exocytosis, Endocytosis, and Vesicle Recycling

Mingzhu Huang et al.

FRONTIERS IN NEUROSCIENCE (2019)

Article Neurosciences

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Sarah H. Shahmoradian et al.

NATURE NEUROSCIENCE (2019)

Article Biochemistry & Molecular Biology

Ganglioside lipids accelerate α-synuclein amyloid formation

Ricardo Gaspar et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2018)

Article Chemistry, Multidisciplinary

Structure of Phospholipid Mixed Micelles (Bicelles) Studied by Small-Angle X-ray Scattering

Henriette G. Mortensen et al.

LANGMUIR (2018)

Review Neurosciences

The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease

Celine Galvagnion

JOURNAL OF PARKINSONS DISEASE (2017)

Article Medicine, General & Internal

Parkinson disease

Werner Poewe et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Biochemistry & Molecular Biology

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

Celine Galvagnion et al.

NATURE CHEMICAL BIOLOGY (2015)

Review Neurosciences

The Synaptic Function of α-Synuclein

Jacqueline Burre

JOURNAL OF PARKINSONS DISEASE (2015)

Review Neurosciences

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

Yong-Bo Hu et al.

TRANSLATIONAL NEURODEGENERATION (2015)

Article Biochemistry & Molecular Biology

Acceleration of α-Synuclein Aggregation by Exosomes

Marie Grey et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Protein/Lipid Coaggregates are Formed During a-Synuclein-Induced Disruption of Lipid Bilayers

Andreas van Maarschalkerweerd et al.

BIOMACROMOLECULES (2014)

Article Chemistry, Multidisciplinary

The Presence of an Air-Water Interface Affects Formation and Elongation of α-Synuclein Fibrils

Silvia Campioni et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Multidisciplinary Sciences

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

Alexander K. Buell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

Giuliana Fusco et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Adsorption of α-Synuclein to Supported Lipid Bilayers: Positioning and Role of Electrostatics

Erik Hellstrand et al.

ACS CHEMICAL NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils

Erik Hellstrand et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation

Naoko Mizuno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Chemistry, Physical

Formfactors of Hollow and Massive Rectangular Parallelepipeds at Variable Degree of Anisometry

Roman Nayuk et al.

ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS (2012)

Article Neurosciences

Membrane Interaction of alpha-Synuclein in Different Aggregation States

Marie Grey et al.

JOURNAL OF PARKINSONS DISEASE (2011)

Article Biochemistry & Molecular Biology

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

Jobin Varkey et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

A study of the regional effects of α-synuclein on the organization and stability of phospholipid bilayers

Jillian Madine et al.

BIOCHEMISTRY (2006)

Article Chemistry, Physical

Vesicle formation from temperature jumps in a nonionic surfactant system

K Bryskhe et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2005)

Article Chemistry, Physical

Refined contour analysis of giant unilamellar vesicles

J Pécréaux et al.

EUROPEAN PHYSICAL JOURNAL E (2004)

Article Biochemistry & Molecular Biology

Direct observation and characterization of DMPC/DHPC aggregates under conditions relevant for biological solution NMR

L van Dam et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

Article Multidisciplinary Sciences

Structure of membrane-bound α-synuclein studied by site-directed spin labeling

CC Jao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Neurosciences

Parkinson's disease: Mechanisms and models

W Dauer et al.

NEURON (2003)

Article Multidisciplinary Sciences

α-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins

R Sharon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

Evidence for a partially folded intermediate in α-synuclein fibril formation

VN Uversky et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)