Omicron subvariants escape antibodies elicited by vaccination and BA.2.2 infection

Article Biochemical Research Methods

CoV-Spectrum: analysis of globally shared SARS-CoV-2 data to identify and characterize new variants

Chaoran Chen et al.

Summary: The CoV-Spectrum website provides support for identifying and tracking new SARS-CoV-2 variants, with flexible mutation search capabilities and analysis on various data sources to understand characteristics and transmission of different variants.

BIOINFORMATICS (2022)

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Article Microbiology

SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies

Prerna Arora et al.

Summary: The Omicron sublineages show comparable cell entry and fusion efficiency and are dependent on ACE2. BA.2 exhibits lower neutralization efficiency by most antibodies used for COVID-19 therapy, while Cilgavimab can effectively neutralize BA.2 and BA.3, potentially serving as a treatment option. Furthermore, all sublineages are similarly neutralized by antibodies induced by the BNT162b2 vaccine.

CELL HOST & MICROBE (2022)

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Article Microbiology

Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2

John P. Evans et al.

Summary: Recent reports show that SARS-CoV-2 Omicron variant sub-lineages BA.1, BA.1.1, and BA.2 have raised concerns about their ability to escape vaccine-induced and infection-induced immunity. A study finds that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit significant immune escape, but this can be largely overcome by mRNA vaccine booster doses. The findings highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insights into the immunity from natural infection against Omicron sub-lineages.

CELL HOST & MICROBE (2022)

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Article Multidisciplinary Sciences

Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern

Xiaoqi Yu et al.

Summary: This study characterizes the neutralizing antibody response to the inactivated SARS-CoV-2 vaccine BBIBP-CorV and assesses its functionality against a range of key SARS-CoV-2 variants. The results show that vaccine-elicited sera have varying degrees of reduction in neutralization against multiple variants, indicating the potential need for additional boost vaccinations.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Differential Antibody Response to Inactivated COVID-19 Vaccines in Healthy Subjects

Jiaqi Zhang et al.

Summary: A study showed that 90.7% of vaccinated individuals had NAb seroconversion, with all participants who seroconverted after the first dose being females with relatively high prevaccine estradiol levels. Individuals without seroconversion tended to have lower lymphocyte counts and higher serum SAA levels. Additionally, young vaccine recipients had significantly higher peak NAb titers compared to elderly recipients.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Omicron subvariants escape antibodies elicited by vaccination and BA.2.2 infection

相关参考文献

CoV-Spectrum: analysis of globally shared SARS-CoV-2 data to identify and characterize new variants

SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies

Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2

Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern

Differential Antibody Response to Inactivated COVID-19 Vaccines in Healthy Subjects

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