4.6 Article

DNA Repair Factor Poly(ADP-Ribose) Polymerase 1 Is a Proviral Factor in Hepatitis B Virus Covalently Closed Circular DNA Formation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Rapid Detection and Signaling of DNA Damage by PARP-1

Nootan Pandey et al.

Summary: PARP-1 is an abundant ADP-ribosyl transfer-ase that plays a key role in DNA damage response. Novel PARP inhibitors can now be designed to treat cell toxicity caused by PARP-1 trapping on DNA.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Article Multidisciplinary Sciences

Hepatitis B virus cccDNA is formed through distinct repair processes of each strand

Lei Wei et al.

Summary: The formation of HBV covalently closed circular DNA (cccDNA) is crucial for chronic infection, but the molecular mechanism behind it is unclear. Researchers found that the repair of plus-strand and minus-strand lesions of HBV rcDNA during the conversion to cccDNA requires different sets of human repair factors.

NATURE COMMUNICATIONS (2021)

Review Virology

Mechanism of Hepatitis B Virus cccDNA Formation

Lei Wei et al.

Summary: Hepatitis B virus (HBV) is a small DNA virus that undergoes a complex replication cycle in human hepatocytes to produce covalently closed circular DNA, relying on host factors for conversion. Research utilizing genetic and biochemical approaches has provided insights into the complex mechanism of HBV cccDNA formation, critical for the development of new therapies towards viral suppression and potential cure.

VIRUSES-BASEL (2021)

Article Virology

Hepatitis B virus-host interactions and novel targets for viral cure

Gaetan Ligat et al.

Summary: Chronic HBV infection is difficult to cure, but targeting host factors to intervene in the viral life cycle may achieve a cure. Current treatments often require long-term use, with risks of drug resistance and side effects, but interferon therapy has a potential for cure.

CURRENT OPINION IN VIROLOGY (2021)

Review Cell Biology

Nuclear PARPs and genome integrity

Kameron Azarm et al.

GENES & DEVELOPMENT (2020)

Review Biotechnology & Applied Microbiology

Hepatitis B vaccine development and implementation

Hong Zhao et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2020)

Review Pharmacology & Pharmacy

Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential

Yuchen Xia et al.

ANTIVIRAL RESEARCH (2020)

Article Cell Biology

Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle

Anindita Chakraborty et al.

CELLULAR MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

Elizaveta E. Alemasova et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Pharmacology & Pharmacy

HDAC11 restricts HBV replication through epigenetic repression of cccDNA transcription

Yifei Yuan et al.

ANTIVIRAL RESEARCH (2019)

Article Microbiology

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus

Kouichi Kitamura et al.

PLOS PATHOGENS (2018)

Article Gastroenterology & Hepatology

Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels

Chunkyu Ko et al.

JOURNAL OF HEPATOLOGY (2018)

Article Biotechnology & Applied Microbiology

Ceruloplasmin inhibits the production of extracellular hepatitis B virions by targeting its middle surface protein

Kaitao Zhao et al.

JOURNAL OF GENERAL VIROLOGY (2017)

Review Biochemistry & Molecular Biology

Mechanistic overview of ADP-ribosylation reactions

Vicky M. -H. Sung

BIOCHIMIE (2015)

Article Genetics & Heredity

Quantitative site-specific ADP-ribosylation profiling of DNA-dependent PARPs

Jean-Philippe Gagne et al.

DNA REPAIR (2015)

Article Gastroenterology & Hepatology

Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine

Scott Bowden et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Biochemistry & Molecular Biology

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis

Marie-France Langelier et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

Ammar A. E. Ali et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Review Gastroenterology & Hepatology

Mechanisms of HBV-related hepatocarcinogenesis

Christine Neuveut et al.

JOURNAL OF HEPATOLOGY (2010)

Review Biochemistry & Molecular Biology

Modulation of transcription by PARP-1:: Consequences in carcinogenesis and inflammation

R. Aguilar-Quesada et al.

CURRENT MEDICINAL CHEMISTRY (2007)

Article Biochemical Research Methods

DNA transitions induced by binding of PARP-1 to cruciform structures in supercoiled plasmids

S Chasovskikh et al.

CYTOMETRY PART A (2005)

Article Gastroenterology & Hepatology

New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA

F Zoulim

JOURNAL OF HEPATOLOGY (2005)

Article Multidisciplinary Sciences

Infection of a human hepatoma cell line by hepatitis B virus

P Gripon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)