期刊
JOURNAL OF VASCULAR SURGERY
卷 76, 期 5, 页码 1170-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jvs.2022.05.008
关键词
Branched; Endovascular aortic repair; Fenestrated; Frailty; Modified frailty index; Outcomes
This study assessed the effects of patient frailty status on the outcomes of fenestrated-branched endovascular aortic repair for complex abdominal and thoracoabdominal aortic aneurysms. The results showed that greater frailty was associated with higher early mortality, major adverse events, and lower long-term survival.
Objective: In the present study, we assessed the effects of patient frailty status on the early outcomes and late survival after fenestrated-branched endovascular aortic repair (FB-EVAR) for complex abdominal and thoracoabdominal aortic aneurysms. Methods: We retrospectively reviewed the clinical data and outcomes of consecutive patients who had undergone elective FB-EVAR from 2007 to 2019 in a single institution. A previously validated 11-item modified frailty index (mFI-11) was derived from the comorbidity and preoperative functional status data. An mFI-11 <0.3 was defined as low risk, 0.3 to 0.5 as medium risk, and >0.5 as high risk. The studied outcomes were 90-day mortality, major adverse events (MAE), and long-term survival. Multivariate analyses were performed to identify the independent predictors of these outcomes. Results: A total of 592 patients (155 women, mean age, 75 +/- 8 years) had undergone FB-EVAR. Using the mFI-11, 310 patients (52%) were included in the low-risk, 199 (34%) in the medium-risk, and 83 (14%) in the high-risk group. The 90-day mortality was significantly higher in the high-risk group than in the medium-and low-risk groups (13%, 4%, and 3%, respectively; P < .01). The corresponding MAE rates were 27%, 18%, and 19% (P 1/4 .23). As a subgroup, 44 patients in the high-risk group had had chronic kidney disease (CKD). The 90-day mortality for these patients was as high as 23%, and 32% had experienced MAE. On multivariable analysis, the independent risk factors for 90-day mortality were CKD, respiratory disease, and a high mFI-11. The independent risk factors for MAE were female sex, CKD, larger aneurysm diameter, and the high-risk subgroup with CKD. The independent risk factors for long-term mortality were age, a low body mass index, CKD, larger aneurysm diameter, extent I-III thoracoabdominal aortic aneurysm, respiratory disease, congestive heart failure, a history of cerebrovascular problems, and higher mFI-11. The estimated survival at 1 year was 91% +/- 2% in the low-risk, 88% +/- 2% in the medium-risk, and 78% +/- 5% in the high-risk group (P < .001). The corre-sponding 5-year survival estimates were 60% +/- 4%, 52% +/- 5%, and 32% +/- 6%. The mean follow-up time was 2.9 +/- 2.3 years. The patients treated during the first quartile of the study period were significantly more frail than were those in the later quartiles. Also, the outcomes of FB-EVAR had improved over time. Conclusions: Greater frailty was significantly associated with early mortality. Together with CKD, frailty was also associ-ated with MAE and lower patient survival after FB-EVAR. The mFI-11 represents the accumulation of comorbidities and can be used to assist in better patient selection for FB-EVAR.
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