期刊
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
卷 102, 期 15, 页码 6795-6803出版社
WILEY
DOI: 10.1002/jsfa.12074
关键词
dietary fiber; gut microbiota; lead exposure; neuroinflammation; brain-gut-microbiota axis; alleviate
资金
- Zhejiang Key R&D Program of China [2020C02037]
- Student Research and Innovation Program of Ningbo University [2021SRIP3611]
Dietary fiber plays a significant role in alleviating lead-induced neuroinflammation by regulating gut microbiota and the immune system, providing a potential dietary protective strategy.
Dietary fiber (DF) is a carbohydrate from the edible part of plants and has the functions of promoting gastrointestinal motility, regulating gut microbiota (GM) and improving health. Lead is a non-essential toxic heavy metal that can accumulate in the environment over time and enter the body through the respiratory tract, skin and gastrointestinal tract. Lead not only causes disturbances in GM but also leads to loss of homeostasis of immune functions, causes neuronal damage and results in neuroinflammation. The scientific literature has reported that DF had anti-inflammatory activity as a natural product. This review highlights the role of DF and its metabolic products in alleviating lead-induced neuroinflammation by inducing changes in the species and quantity of GM and regulating the immune system, providing a potential dietary protective strategy for lead-induced disease. (c) 2022 Society of Chemical Industry.
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