4.5 Review

The Role of Immunotherapy in the Management of Soft Tissue Sarcomas: Current Landscape and Future Outlook

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

A Randomized Phase II Study of Nivolumab Monotherapy or Nivolumab Combined with Ipilimumab in Patients with Advanced Gastrointestinal Stromal Tumors

Arun S. Singh et al.

Summary: This study analyzed the efficacy of nivolumab or nivolumab combined with ipilimumab in patients with refractory gastrointestinal stromal tumors (GIST). The results showed that both nivolumab and nivolumab combined with ipilimumab could effectively control the disease in heavily pretreated GIST patients.

CLINICAL CANCER RESEARCH (2022)

Article Oncology

Phase II Randomized Study of CMB305 and Atezolizumab Compared With Atezolizumab Alone in Soft-Tissue Sarcomas Expressing NY-ESO-1

Sant P. Chawla et al.

Summary: This study investigated the efficacy and safety of combining the CMB305 regimen with atezolizumab compared to atezolizumab alone in patients with synovial sarcoma or myxoid liposarcoma. The combination therapy resulted in improved NY-ESO-1-specific T-cell and antibody responses, but did not significantly increase progression-free survival or overall survival compared to atezolizumab alone.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Multidisciplinary Sciences

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs

Mark Yarmarkovich et al.

Summary: The majority of oncogenic drivers are intracellular proteins, thus limiting immunotherapeutic targeting. However, targeting non-immunogenic intracellular oncoproteins like PHOX2B using peptide-centric CARs shows promise in expanding immunotherapeutic targets and potentially benefiting a wider range of patients by breaking conventional HLA restriction.

NATURE (2021)

Article Oncology

Case Report: Response to Regional Melphalan via Limb Infusion and Systemic PD1 Blockade in Recurrent Myxofibrosarcoma: A Report of 2 Cases

Edmund K. Bartlett et al.

Summary: Limited treatment options are available for patients with advanced sarcoma. However, a combination treatment of regionally administered melphalan and pembrolizumab showed promising responses in two patients with multiply recurrent myxofibrosarcoma, including significant partial and complete responses. Post-treatment biopsies revealed immune infiltration into the tumors, leading to the development of a clinical trial to further study this combination treatment.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Phase II Study of Pembrolizumab in Combination with Doxorubicin in Metastatic and Unresectable Soft-Tissue Sarcoma

Michael B. Livingston et al.

Summary: Combining pembrolizumab and doxorubicin in the treatment of advanced soft-tissue sarcoma patients showed manageable toxicity and preliminary promising activity, with potential therapeutic benefits for patients who have not received anthracycline therapy before.

CLINICAL CANCER RESEARCH (2021)

Meeting Abstract Oncology

A phase 2 study of talimogene laherparepvec, nivolumab, and trabectedin (TNT) in advanced sarcoma.

Neal Shiv Chawla et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Meeting Abstract Oncology

Phase II study of atezolizumab in advanced alveolar soft part sarcoma (ASPS).

Abdul Rafeh Naqash et al.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Multidisciplinary Sciences

Radiation-induced neoantigens broaden the immunotherapeutic window of cancers with low mutational loads

Danielle M. Lussier et al.

Summary: Immunotherapies show promise in cancer treatment, particularly in highly mutated tumors. Radiation therapy can induce mutant neoantigens in tumor cells, making them more susceptible to immune checkpoint therapy, demonstrating additional mechanisms for the synergy between radiation and immunotherapy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Oncology

Multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART)

Michael J. Wagner et al.

Summary: A prospective study using ipilimumab and nivolumab as treatment for angiosarcoma showed an objective response rate of 25% and potential adverse events.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Medicine, Research & Experimental

CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia

Melinda A. Biernacki et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Pathology

Characteristics of mismatch repair deficiency in sarcomas

Leona A. Doyle et al.

MODERN PATHOLOGY (2019)

Article Biochemistry & Molecular Biology

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

Wei Yang et al.

NATURE MEDICINE (2019)

Review Immunology

T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance

Smita S. Chandran et al.

IMMUNOLOGICAL REVIEWS (2019)

Article Oncology

Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma

Indu Ramachandran et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Oncology

Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O'Donnell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

Translocation-Related Sarcomas

Kenji Nakano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

Chemotherapy for Soft Tissue Sarcoma

Ravin Ratan et al.

CANCER (2016)

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

Article Oncology

Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy

Richard A. Morgan et al.

JOURNAL OF IMMUNOTHERAPY (2013)

Article Medicine, General & Internal

Safety and Tumor Responses with Lambrolizumab (Anti-PD-1) in Melanoma

Omid Hamid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Multidisciplinary Sciences

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

Robert D. Schreiber et al.

SCIENCE (2011)

Article Medicine, Research & Experimental

Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors

Keith M. Skubitz et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2008)

Article Oncology

Immunotherapy with autologous dendritic cells and tumor-specific synthetic peptides for synovial sarcoma

A Matsuzaki et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2002)