期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 131, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jmbbm.2022.105255
关键词
Flow mediated dilation; Fluid-structure interaction; Mechanotransduction; Wall shear stress; Viscoelastic model
资金
- National Science Foundation's [2003077, 1511096]
- National Institute of Health [R21 EB005326]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [2003077] Funding Source: National Science Foundation
In this study, mechanotransduction is investigated using a viscoelastic model to describe the arterial diameter response during a brachial artery flow mediated dilation (BAFMD) test. The results show that the mechanical behavior of the arterial wall is predominantly elastic.
In this study, mechanotransduction is investigated through a physics-based viscoelastic model describing the arterial diameter response during a brachial artery flow mediated dilation (BAFMD) test. The study is a significant extension of two earlier studies by the same group, where only the elastic response was considered. Experimental BAFMD responses were collected from 12 healthy volunteers. The arterial wall's elastic and viscous properties were treated as local variable quantities depending on the wall shear stress (WSS) sensed by mechanotransduction. The dimensionless parameters, arising from the model which serve as a quantitative assessment of the artery's physical state, were adjusted to replicate the experimental response. Among those dimensionless parameters, the viscoelastic ratio, which reflects the relative strength of the viscous response compared to its elastic counterpart, is of special relevance to this paper's main conclusion. Based on the results, it is concluded that the arterial wall's mechanical behavior is predominantly elastic, at least in the strict context of the BAFMD test. Recommendations for potential future research and applications are provided.
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