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Genetic evidence of a sarcomatoid transformation in Merkel cell carcinoma

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

Genomic evidence suggests that cutaneous neuroendocrine carcinomas can arise from squamous dysplastic precursors

Paul W. Harms et al.

Summary: MCC and SCCIS show significant overlap in gene mutations, with no unique gene mutations found in all cases of MCC. Transcriptome analysis reveals large differences in gene expression between MCC and SCCIS, including epidermal markers and immune genes. Immunohistochemistry studies show increased expression of SOX2 in the MCC component.

MODERN PATHOLOGY (2022)

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Article Biochemistry & Molecular Biology

DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma

Jan Gravemeyer et al.

Summary: Analysis of DNA methylation suggests a common epithelial origin of UV- and VP-MCC cell lines.

ONCOGENE (2022)

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Article Dermatology

Merkel Cell Polyomavirus-Negative Merkel Cell Carcinoma Originating from In Situ Squamous Cell Carcinoma: A Keratinocytic Tumor with Neuroendocrine Differentiation

Thibault Kervarrec et al.

Summary: The study reveals the association between virus-negative Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC), suggesting a common origin. RB1 inactivation in SCC facilitates MCC development and epigenetic changes contribute to the transition from SCC to MCC.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Pathology