期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 79, 期 23, 页码 2310-2321出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2022.03.381
关键词
angiography; atherosclerosis; cardiac CT; cardiovascular disease; preeclampsia; women
资金
- Danish Heart Foundation
- Skibsreder Per Henriksen
- R og Hustrus Fond
- Kong Christian den Tiendes Fond
- Brodrene Hartmanns Fond
- Hans og Nora Buchards Fond
- Arvid Nilssons Fond
- Anita og Tage Therkelsens Fond
- Fonden til Laegevidenskabens Fremme
- Aase og Ejnar Danielsens Fond
- Hjertecentrets Forskningsudvalg (Rigshospitalet)
- Direktor Kurt Bonnelycke og Hustru Fru Grethe Bonnelyckes Fond
- Laegeforeningens Forskningsfond
- Torben and Alice Frimodt Fond
- Henry og Astrid Mollers Fond
- AP Moller og hustru Chastine McKinney Mollers Fond
- Research Council of Rigshopitalet
- University of Copenhagen
This study found that younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared to women from the general population. Preeclampsia remained an independent risk factor for coronary atherosclerosis after adjusting for traditional cardiovascular risk factors.
BACKGROUND Women with previous preeclampsia have an increased risk of coronary artery disease later in life. OBJECTIVES This study aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population. METHODS Women aged 40-55 years with previous preeclampsia were matched 1:1 on age and parity with women from the general population. Participants completed an extensive questionnaire, a clinical examination, and a coronary computed tomography angiography (CTA). The main study outcome was the prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in case of a nondiagnostic coronary CTA. RESULTS A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population). Women with previous preeclampsia were more likely to have hypertension (284 [40.1%] vs 162 [22.8%]; P < 0.001), dyslipidemia (338 [47.7%] vs 296 [41.7%]; P = 0.023), diabetes mellitus (24 [3.4%] vs 8 [1.1%]; P = 0.004), and high body mass index (27.3 +/- 5.7 kg/m(2) vs 25.0 +/- 4.2 kg/m(2); P < 0.001). Cardiac computed tomography was performed in all women. The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (193 [27.4%] vs 141 [20.0%]; P = 0.001) with an OR: 1.41 (95% 0: 1.08-1.85; P = 0.012) after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity. CONCLUSIONS Younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared with age- and parity-matched women from the general population. Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors. (C) 2022 by the American College of Cardiology Foundation.
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