期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c05044
关键词
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资金
- National Institute of General Medical Sciences of the National Institutes of Health [R35 GM138350]
- Colorado State University (CSU)
- Research Corporation for Science Advancement (Cottrell Scholar Award)
We reported a trifluoromethylarene reductive coupling method that expands the scope of difluorobenzylic substructures accessible, providing rapid access to over 20 unique difluoroalkylarene scaffolds.
We report a trifluoromethylarene reductive coupling method that dramatically expands the scope of difluorobenzylic substructures accessible via C-F bond functionalization. Catalytic quantities of a Lewis base, combined with a disilane reagent in formamide solvent, promotes the replacement of a single trifluoromethyl fluorine atom with a silylated hemiaminal functional group. The reaction proceeds through a difluorobenzyl silane intermediate that can also be isolated. Together, these defluorinated products are shown to provide rapid access to over 20 unique difluoroalkylarene scaffolds.
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