Neutrophil-to-lymphocyte ratio predicts in-hospital mortality in intracerebral hemorrhage

Objectives: The neutrophil-to-lymphocyte ratio is gaining popularity as a low-cost biomarker of inflammation and outcome prediction. Intracerebral hemorrhage has high mortality and disability, which strongly influences societal development. This study aimed to research whether the neutrophil-to-lymphocyte ratio can predict hospital mortality in patients with severe intracerebral hemorrhage. Materials and methods: It was a retrospective analysis of prospectively collected data. The survival analysis and proportional hazards models analyzed clinical data from the Medical Information Mart for Intensive Care III database of patients with intracerebral hem-orrhage. Results: The records of 1,000 patients were included in our study. Two hun-dred forty-seven individuals died in the hospital, while 753 survived to discharge. According to data analysis, the neutrophil-to-lymphocyte ratio of the death group (11.21 +/- 7.81) significantly exceeded the survival group (7.94 +/- 6.04). The univariate Cox regression revealed that the neutrophil-to-lymphocyte ratio is a potential pre-dictor of in-hospital mortality (HR:1.044; 95% CI:1.029-1.059; p <0.001). Further-more, the proportional hazards model demonstrated that the risk of in-hospital death increased 2.34-fold for each increase in neutrophil-to-lymphocyte ratio when other factors were held constant. Following the ROC analysis, the Kaplan-Meier based on the proportional hazards model showed that patients with a neutrophil-to-lymphocyte ratio >7.68 on the first day of hospitalization had a higher risk of death. Conclusions: In patients with severe intracerebral hemorrhage, the neutro-phil-to-lymphocyte ratio is a potential predictor of in-hospital mortality.

Automated summary

This study aimed to investigate the potential of neutrophil-to-lymphocyte ratio as a predictor of in-hospital mortality in patients with severe intracerebral hemorrhage. The results showed that a higher neutrophil-to-lymphocyte ratio was associated with an increased risk of in-hospital death, indicating its potential as a biomarker for outcome prediction.