期刊
JOURNAL OF SEPARATION SCIENCE
卷 45, 期 18, 页码 3382-3392出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.202200336
关键词
active constituents; epimedium; liquid chromatography tandem mass spectrometry; pharmacokinetics; synergistic and attenuating
资金
- National Natural Science Foundation of China [81373942]
- Key Science and Technology Research Projects of Tibet Autonomous Region of China [XZ201801-GA-16]
The pharmacokinetic characteristics of Epimedium and Ligustri lucidi fructus were investigated in this study to explore their possible synergism and reduction in toxicity. The results showed that the combination of these two herbs may change the absorption and metabolic pathways of the drugs, and the addition of Ligustri lucidi fructus could decrease the toxicity of Epimedium.
Epimedium has a wide range of clinical applications; however, there have been numerous reports of adverse reactions in recent years, which has resulted in it being changed from a widely recognized nontoxic to a potentially toxic traditional Chinese medicine. The combination of Epimedium and Ligustri lucidi fructus is commonly used in the clinic. The purpose of this study was to investigate the pharmacokinetic characteristics of Epimedium and Ligustri lucidi fructus to explore the possible synergism and reduction in toxicity. Based on liquid chromatography tandem mass spectrometry, a method was established for the determination of icariin, epimedin A, epimedin B, epimedin C, baohuoside I, and specnuezhenide in biological samples and was successfully applied to study the pharmacokinetics of the drug pair. The results showed that the five flavonoids (specnuezhenide could not be detected) could be rapidly absorbed into the blood, and the second peak time in vivo was earlier after the combination, indicating that the metabolic pathway may be changed. In addition, combination with Ligustri lucidi fructus could significantly reduce the concentration of 5 flavonoids in vivo and increase their elimination rate, which may attenuate their virulence, thus providing a reference for the rational clinical use of Epimedium.
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