期刊
JOURNAL OF CRANIOFACIAL SURGERY
卷 27, 期 7, 页码 1759-1764出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SCS.0000000000003066
关键词
Nerve regeneration; PRF; rat; sciatic nerve
类别
资金
- Kirikkale University, Scientific Project Department [201299]
Purpose:This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses.Materials and Methods:Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n=10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n=10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n=10). Functional, histopathologic, and electrophysiologic analyses were performed.Results:The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P<0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P<0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results.Conclusion:The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.
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