期刊
JOURNAL OF PATHOLOGY
卷 258, 期 1, 页码 4-11出版社
WILEY
DOI: 10.1002/path.5981
关键词
HEV-finder; artificial intelligence (AI); deep learning; high endothelial venules (HEVs); tumor-draining lymph nodes (TDLNs); breast cancer; vascular remodeling
资金
- BioImage Informatics Facility, a unit of the National Bioinformatics Infrastructure Sweden NBIS
- SciLifeLab
- National Microscopy Infrastructure NMI [VR-RFI 2019-00217]
- Swedish Research Council [2016-02492]
- Swedish Cancer Foundation [2017/759, 0970 PjF]
- Kjell and Marta Beijer Foundation
- Chan-Zuckerberg Initiative
- Swedish Research Council [2016-02492] Funding Source: Swedish Research Council
Vascular remodeling is common in human cancer and has potential as future biomarkers for disease progression and tumor immunity status. A fully automated tool named HEV-finder can detect and classify high endothelial venule (HEV) dilation in tumor-draining lymph nodes, laying the groundwork for exploration of HEV dilation as a biomarker.
Vascular remodeling is common in human cancer and has potential as future biomarkers for prediction of disease progression and tumor immunity status. It can also affect metastatic sites, including the tumor-draining lymph nodes (TDLNs). Dilation of the high endothelial venules (HEVs) within TDLNs has been observed in several types of cancer. We recently demonstrated that it is a premetastatic effect that can be linked to tumor invasiveness in breast cancer. Manual visual assessment of changes in vascular morphology is a tedious and difficult task, limiting high-throughput analysis. Here we present a fully automated approach for detection and classification of HEV dilation. By using 12,524 manually classified HEVs, we trained a deep-learning model and created a graphical user interface for visualization of the results. The tool, named the HEV-finder, selectively analyses HEV dilation in specific regions of the lymph nodes. We evaluated the HEV-finder's ability to detect and classify HEV dilation in different types of breast cancer compared to manual annotations. Our results constitute a successful example of large-scale, fully automated, and user-independent, image-based quantitative assessment of vascular remodeling in human pathology and lay the ground for future exploration of HEV dilation in TDLNs as a biomarker. (c) 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据