PPh3-Triggered Tandem Synthesis of 2,3-Disubstituted Benzofuran Derivatives from o-Quinone Methides with Acyl Chlorides

A PPh3-triggered tandem strategy for the efficient synthesis of valuable 2,3-disubstituted benzofuran derivatives in generally good to high yields from aryl or alkyl acyl chlorides and o-quinone methides has been developed. This method features mild reaction conditions, simple operation, and a broad substrate scope.

Automated summary

A PPh3-triggered tandem strategy has been developed for the efficient synthesis of valuable 2,3-disubstituted benzofuran derivatives from aryl or alkyl acyl chlorides and o-quinone methides. This method features mild reaction conditions, simple operation, and a broad substrate scope.