4.7 Article

TEMPO-Promoted Mono- and Bisimidation of Tertiary Anilines: Synthesis of Symmetric and Unsymmetric N-Mannich Bases

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Summary: TEMPO and its derivatives are active catalysts for electrophilic halogenation of olefins, alkynes, and aromatics, under mild reaction conditions and with good functional group tolerance. The high catalytic ability is attributed to a synergistic activation model of electrophilic halogenating reagents. Organohalides are widely used as synthetic precursors and target products, and effective catalysts are needed to activate commercially available haleniums for various halogenation reactions.

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