Electrochemically Enabled Cascade Cyclization Reaction of Aromatic Aldehydes and Pyrazol-5-amines: Synthesis of Bis- pyrazolo[3,4-b:4',3'-e]pyridines

A facile method for the synthesis of bis-pyrazolo-[3,4-b:4',3'-e]pyridines from easily available aromatic aldehydes and pyrazol-5-amines was developed via electrochemistry. The reaction proceeded smoothly under metal and external chemical oxidant-free conditions, giving a variety of bis-pyrazolo[3,4-b:4',3'- e]pyridines in moderate yields.

Automated summary

A facile method for the synthesis of bis-pyrazolo[3,4-b:4',3'-e]pyridines from easily available aromatic aldehydes and pyrazol-5-amines was developed via electrochemistry, resulting in moderate yields.