期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 14, 页码 9023-9033出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c00704
关键词
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资金
- Frontier Research on Chemical Communication [17H06406]
- Middle Molecular Strategy ? [18H04400]
- MEXT
- MEXT [17H06406, 18H04400, 19H02896]
- Nagoya University
The collective synthesis of four spiro-cyclic guanidines isolated from puffer fish, which are considered possible biosynthetic intermediates of tetrodotoxin, has been achieved through stepwise deoxygenation or hydroxylation of a common intermediate.
The collective synthesis of the four spiro-cyclic guanidines Tb-210B, Tb-226, Tb-242C, and Tb-258, all of which have been isolated from puffer fish and are considered possible biosynthetic intermediates of tetrodotoxin, has been achieved. Our synthesis is based on the stepwise deoxygenation or hydroxylation of a common intermediate, prepared from a known oxazoline.
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