4.7 Article

Total Syntheses of the Proposed Biosynthetic Intermediates of Tetrodotoxin Tb-210B, Tb-226, Tb-242C, and Tb-258

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JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 14, 页码 9023-9033

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.2c00704

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  1. Frontier Research on Chemical Communication [17H06406]
  2. Middle Molecular Strategy ? [18H04400]
  3. MEXT
  4. MEXT [17H06406, 18H04400, 19H02896]
  5. Nagoya University

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The collective synthesis of four spiro-cyclic guanidines isolated from puffer fish, which are considered possible biosynthetic intermediates of tetrodotoxin, has been achieved through stepwise deoxygenation or hydroxylation of a common intermediate.
The collective synthesis of the four spiro-cyclic guanidines Tb-210B, Tb-226, Tb-242C, and Tb-258, all of which have been isolated from puffer fish and are considered possible biosynthetic intermediates of tetrodotoxin, has been achieved. Our synthesis is based on the stepwise deoxygenation or hydroxylation of a common intermediate, prepared from a known oxazoline.

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