期刊
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
卷 48, 期 11, 页码 2738-2747出版社
WILEY
DOI: 10.1111/jog.15380
关键词
gestational diabetes; logistic regression; nomogram; nomograms; risk factors
资金
- Department of Clinical Laboratory
The aim of this study was to develop a risk prediction model for gestational diabetes mellitus (GDM) based on common maternal demographics and routine clinical variables in the Chinese population. A predictive model for GDM was established using multivariable logistic regression analysis, and the consistency and discriminative validity of the model were evaluated. The model exhibited good predictive ability, discriminative performance, and clinical utility.
Aim: We aimed to develop a risk prediction model for gestational diabetes mellitus (GDM) based on the common maternal demographics and routine clinical variables in Chinese population. Methods: Individual information was collected from December 2018 to October 2019 by a pretested questionnaire on demographics, medical and family history, and lifestyle factors. Multivariable logistic regression was performed to establish a predictive model for GDM by variables in pre- and early pregnancy. The consistency and discriminative validity of the model were evaluated by Hosmer-Lemeshow goodness-of-fit testing and ROC curve analysis. Internal validation was appraised by fivefold cross-validation. Clinical utility was assessed by decision curve analysis. Results: Total 3263 pregnant women were included with 17.2% prevalence of GDM. The model equation was: LogitP = -11.432 + 0.065 x maternal age (years) + 0.061 x pre-pregnancy BMI (kg/m(2)) + -0.055 x weight gain in early pregnancy (kg) + 0.872 x history of GDM + 0.336 x first-degree family history of diabetes +0.213 x sex hormone usages during pre- or early pregnancy + 1.089 x fasting glucose (mmol/L) + 0.409 x triglycerides (mmol/L) + 0.082 x white blood cell count (109/L) + 0.669 x positive urinary glucose. Homer-Lemeshow goodness-of-fit testing indicated a good consistency between predictive and actual data (p = 0.586). The area under the ROC curve (AUC) was 0.720 (95% CI: 0.697 similar to 0.744). Cross-validation suggested a good internal validity of the model. A nomogram has been made to establish an easy to use scoring system for clinical practice. Conclusions: The predictive model of GDM exhibited well acceptable predictive ability, discriminative performance, and clinical utilities. The project was registered in clinicaltrial.gov.com with identifier of NCT03922087.
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