4.5 Article

Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs

期刊

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
卷 44, 期 8, 页码 1095-1103

出版社

CHURCHILL LIVINGSTONE
DOI: 10.1016/j.jcms.2016.05.025

关键词

Primary stability; Osseointegration; Dental implants; Polylactide modified bone; 70/30 poly(L-lactide-co-D, 1-lactide)

资金

  1. Thommen Medical AG, Grenchen, Switzerland

向作者/读者索取更多资源

The present study aimed to evaluate primary stability (PS) and osseointegration of dental implants in polylactide [70/30 poly(L-lactide-co-o, L-lactide); (PLDLA)1 modified bone in 30 Goettingen minipigs. Each animal received three implants per jaw quadrant. In a split -mouth design, one side of the maxilla and mandible was randomly allocated to the experimental treatment (PLDLA applied into the drill hole before implantation), while the contralateral sides served as intraindividual controls (no PLDLA applied). The required insertion torque and the implant stability quotient (ISQ) were measured during implantation. ISQ volume density (VD) of new bone formation (NBF), and the bone -implant contact (BIC) were evaluated at the end of the observation period (1, 3, 6, 12, and 24 months, respectively) in six animals each. Across all study groups, the PLDLA treatment resulted in a) a comparable insertion torque, b) an equivalent ISQ c) a reduced BIC, and d) a reduced VD of NBF, as opposed to the untreated controls. In conclusion, the PLDLA treatment did not affect the PS, but rather led to an impaired osseointegration, which was particularly strong in the compact mandibular bone, and decreased in the spongious maxillary bone. PLDLA induced anchoring in spongious bone should be evaluated in further investigations. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

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