期刊
JOURNAL OF NEUROPHYSIOLOGY
卷 128, 期 3, 页码 593-610出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00423.2021
关键词
hippocampus; interneurons; rhythms; spike-phase relationships; statistical modeling
资金
- Frontiers of Innovation Scholars Program, FISP
- Hellman Fellowship
- Kavli Institute for Brain and Mind
- National Institutes of Health
- National Institutes of Mental Health [R01MH1105142]
- National Science Foundation Graduate Research Fellowship Program [R03MH120406, MH052090]
- National Science Foundation
- National Science Foundation Science of Learning Center [DMS-1042134]
- Temporal Dynamics of Learning Center [SBE 0542013]
This study innovatively proposes a modeling approach to test the relationship between local field potential (LFP) oscillations and neuronal spike timing. By relating spike timing with the phase of LFP rhythms and combining short spike history information, researchers can effectively test the reliability of LFP in explaining variance in neuronal spike trains.
Neurons are embedded in complex networks, where they participate in repetitive, coordinated interactions with other neurons. Neuronal spike timing is thus predictably constrained by a range of ionic currents that shape activity at both short (milliseconds) and longer (tens to hundreds of milliseconds) timescales, but we lack analytical tools to rigorously identify these relationships. Here, we innovate a modeling approach to test the relationship between oscillations in the local field potential (LFP) and neuro-nal spike timing. We use kernel density estimation to relate single neuron spike timing and the phase of LFP rhythms (in simu-lated and hippocampal CA1 neuronal spike trains). We then combine phase and short (3 ms) spike history information within a logistic regression framework ( phaseSH models ), and show that models that leverage refractory constraints and oscillatory phase information can effectively test whether-and the degree to which-rhythmic currents (as measured from the LFP) reliably explain variance in neuronal spike trains. This approach allows researchers to systematically test the relationship between oscil-latory activity and neuronal spiking dynamics as they unfold over time and as they shift to adapt to distinct behavioral conditions. NEW & NOTEWORTHY Statistical models that incorporate neural spiking history and relationships to the phase of ongoing oscillations in the local field potential robustly capture and predict neuronal engagement in rhythmic processes. These models constitute a powerful tool to systematically test explicit hypotheses regarding the specific rhythmic currents that constrain neural spiking activity over time and during different behaviors.
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