4.7 Article

The complex relationship between antibody titers and clinical outcome in botulinum toxin type A long-term treated patients with cervical dystonia

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Clinical Improvement After Treatment With IncobotulinumtoxinA (XEOMIN®) in Patients With Cervical Dystonia Resistant to Botulinum Toxin Preparations Containing Complexing Proteins

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Summary: This study focused on investigating the long-term clinical effect of incobotulinumtoxinA in 33 cervical dystonia patients who had experienced partial secondary therapy failure under previous long-term botulinum toxin treatment. Despite some patients showing an increase in neutralizing antibody titres, repeated treatment with low dose incobotulinumtoxinA over 48 weeks resulted in a beneficial clinical long-term effect, with improvements in symptoms and quality of life for the patients.

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