MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

Review Medicine, Research & Experimental

MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets

Sen Liu et al.

Summary: Alzheimer's disease is a common neurodegenerative disease affecting millions worldwide. Recent studies have shown differential abundance and varieties of miRNAs in central and peripheral tissues of AD patients.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Cell Biology

An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

Keliang Pang et al.

Summary: The lack of predictive and translatable animal models has been a major obstacle in Alzheimer's disease (AD) research. While transgenic mice overexpressing App gene do not reflect disease progression accurately, the App knock-in rat model with humanized A beta sequence shows promise in mimicking AD pathologies and progression, including A beta plaques, tau pathology, neuronal death, and cognitive deficits. This rat model may provide valuable insights for AD research and drug development.

CELL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease

Qin Ouyang et al.

Summary: Alzheimer's disease (AD) is a common form of dementia in elderly individuals, with no effective treatment currently available. This study presents a novel DNA nanoflowers-based delivery system for AD therapy, which allows exogenous supplementation of miR-124 to ameliorate AD-like pathology. The nanosystem demonstrates promising results in increasing miR-124 levels in the brain and achieving robust therapeutic efficacy in a mouse model of AD.

SMALL (2022)

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Editorial Material Hematology

MicroRNA-Based Regulation of Embryonic Endothelial Cell Heterogeneity at Single-Cell Resolution

Thomas Walchli et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction

Rui Song et al.

Summary: MicroRNA-210 protects the heart from myocardial ischemia-reperfusion injury by controlling mitochondrial bioenergetics and ROS flux. Deficiency of microRNA-210 exacerbates cardiac dysfunction, while glycerol-3-phosphate dehydrogenase plays a key role in this process.

CIRCULATION (2022)

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Article Clinical Neurology

Polygenic risk of Alzheimer's disease in the Faroe Islands

Malan Johansen et al.

Summary: This study revealed the association of APOE and immunogenomic variability with AD and dementia risk in the Faroe Islands. The PRS+APOE based on SNP analysis showed excellent sensitivity and specificity for the diagnosis of AD. High PRSs were also associated with an earlier onset of late-onset AD.

EUROPEAN JOURNAL OF NEUROLOGY (2022)

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Article Biochemistry & Molecular Biology

Post-Transcriptional Regulation of Molecular Determinants during Cardiogenesis

Estefania Lozano-Velasco et al.

Summary: This article reviews the contribution of non-coding RNAs, including miRNAs and lncRNAs, to cardiac development. These non-coding RNAs modulate major growth factor signaling pathways and transcriptional regulators involved in cardiac morphogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

DIANA-miTED: a microRNA tissue expression database

Ioannis Kavakiotis et al.

Summary: microRNAs are short non-coding RNAs that regulate gene expression post-transcriptionally, and DIANA-miTED is a comprehensive collection of miRNA expression values from various datasets, serving as a valuable resource for researchers.

NUCLEIC ACIDS RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis

Song-Tao Xue et al.

Summary: ESCC was found to have dysregulated expression of lncRNAs, with LINC00680 being highly expressed and associated with poor prognosis. LINC00680 acts as a ceRNA by sponging miR-423-5p to regulate PAK6 expression in ESCC cells, suggesting its potential as a diagnostic, prognostic, and therapeutic target for ESCC.

MOLECULAR CANCER (2022)

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Article Multidisciplinary Sciences

Could drugs prevent Alzheimer’s? These trials aim to find out

Alison Abbott

NATURE (2022)

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Article Geriatrics & Gerontology

MicroRNA modulation is a potential molecular mechanism for neuroprotective effects of intranasal insulin administration in amyloid ?eta oligomer induced Alzheimer's like rat model

Maryam Bazrgar et al.

Summary: Insulin can improve memory impairment in AD patients by regulating the expression of miR-132, miR-181b, and miR-125b, attenuating amyloid-beta aggregation, tau pathology, neuroinflammation, and synaptic dysfunction.

EXPERIMENTAL GERONTOLOGY (2022)

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Article Medicine, Research & Experimental

Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant mice

Hao-Yu Zou et al.

Summary: This study identifies the miR-339-5p/Nnat pathway as a crucial factor in the development of familial AD, highlighting its potential as a diagnostic and therapeutic target for early pathogenesis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Cell & Tissue Engineering

Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease

Hannah Walgrave et al.

Summary: Neural stem cells in the hippocampal neurogenic niche play a crucial role in lifelong neurogenesis, while miR-132 has been identified as a significant regulator affecting hippocampal neurogenesis in Alzheimer's disease. Research demonstrates that replacing miR-132 can restore neurogenesis and memory deficits in the hippocampus of AD mice, highlighting the potential therapeutic efficacy of targeting miR-132 in neurodegenerative diseases.

CELL STEM CELL (2021)

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Review Biotechnology & Applied Microbiology

Coding and non-coding nucleotides': The future of stroke gene therapeutics

Vishal Chavda et al.

Summary: Stroke is a leading cause of death that requires immediate medical attention. Advances in stroke therapy in recent years have focused on genetic therapies and various anti-stroke agents for better outcomes.

GENOMICS (2021)

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Review Clinical Neurology

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

Christina M. Moloney et al.

Summary: Neurofibrillary tangles, a hallmark of Alzheimer's disease, undergo a dynamic process of maturity that impacts neuron biology and cognitive function. The levels of maturity include pretangles, mature tangles, and ghost tangles, with distinct characteristics observed through tau protein immunostaining and morphologic changes. Post-translational modifications of tau play a significant role in therapeutic targeting strategies for cognitive dysfunction.

ALZHEIMERS & DEMENTIA (2021)

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Article Clinical Neurology

Predicting progression and cognitive decline in amyloid-positive patients with Alzheimer's disease

Hakon Valur Dansson et al.

Summary: The study found that CSF levels of A beta are not strong predictors of the rate of cognitive decline in A beta-positive subjects when adjusting for other variables. Baseline assessments of cognitive function can explain 2-year cognitive decline, but are not sufficient for achieving optimal results in longer-term predictions. Predicting changes both in cognitive test scores and in diagnosis provides multiple perspectives of the progression of potential AD subjects.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Review Behavioral Sciences

Behavioural and psychological symptoms of dementia in mouse models of Alzheimer's disease-related pathology

Filip Kosel et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

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Article Biochemistry & Molecular Biology

The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene

Jeong Su Byun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Neurosciences

Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease

Jingcong Zhuang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Review Neurosciences

NF-kappa B as a Key Mediator of Brain Inflammation in Alzheimer's Disease

Chul Ju Hwang et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2019)

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Article Biochemical Research Methods

Suspension Trapping (S-Trap) Is Compatible with Typical Protein Extraction Buffers and Detergents for Bottom-Up Proteomics

Dalia Elinger et al.

JOURNAL OF PROTEOME RESEARCH (2019)

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Article Clinical Neurology

Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid

Petros Takousis et al.

ALZHEIMERS & DEMENTIA (2019)

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Article Genetics & Heredity

A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data

Daichi Shigemizu et al.

BMC MEDICAL GENOMICS (2019)

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Article Clinical Neurology

MiR-22-3p Regulates Amyloid β Deposit in Mice Model of Alzheimer's Disease by Targeting Mitogen-activated Protein Kinase 14

Qiling Ji et al.

CURRENT NEUROVASCULAR RESEARCH (2019)

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Tau impairs neural circuits, dominating amyloid-beta effects, in Alzheimer models in vivo

Marc Aurel Busche et al.

NATURE NEUROSCIENCE (2019)

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Article Clinical Neurology

Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States

Ron Brookmeyer et al.

ALZHEIMERS & DEMENTIA (2018)

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Article Biotechnology & Applied Microbiology

Inhibition of microRNA-384-5p alleviates osteoarthritis through its effects on inhibiting apoptosis of cartilage cells via the NF-kappa B signaling pathway by targeting SOX9

Weikai Zhang et al.

CANCER GENE THERAPY (2018)

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Article Oncology

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia

Raj Bhayadia et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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natureOUTLOOK ALZHEIMER'S DISEASE

Richard Hodson

NATURE (2018)

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Article Neurosciences

A 9-microRNA Signature in Serum Serves as a Noninvasive Biomarker in Early Diagnosis of Alzheimer's Disease

Rui Guo et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Review Cell Biology

The role of the immune system in Alzheimer disease: Etiology and treatment

Stefan Jevtic et al.

AGEING RESEARCH REVIEWS (2017)

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Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology

Elizabeth E. Spangenberg et al.

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β-amyloid increases neurocan expression through regulating Sox9 in astrocytes: A potential relationship between Sox9 and chondroitin sulfate proteoglycans in Alzheimer's disease

Han Yan et al.

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Review Biochemistry & Molecular Biology

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Proteomic Analysis of Solid Pseudopapillary Tumor of the Pancreas Reveals Dysfunction of the Endoplasmic Reticulum Protein Processing Pathway

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MicroRNA-mediated down-regulation of M-CSF receptor contributes to maturation of mouse monocyte-derived dendritic cells

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Article Pathology

Transcriptional Up-Regulation of Sox9 by NF-κB in Endometrial Carcinoma Cells, Modulating Cell Proliferation Through Alteration in the p14ARF/p53/p21WAF1 Pathway

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Profiling of immune-related microRNA expression in human cord blood and adult peripheral blood cells upon proinflammatory stimulation

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EUROPEAN JOURNAL OF HAEMATOLOGY (2012)

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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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miR-22 Controls Irf8 mRNA Abundance and Murine Dendritic Cell Development

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Fast and effective prediction of microRNA/target duplexes

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A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

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MicroRNA-22-3p ameliorates Alzheimer's disease by targeting SOX9 through the NF-κB signaling pathway in the hippocampus

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