期刊
JOURNAL OF NATURAL PRODUCTS
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.2c00322
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资金
- Natural Science Foundation of Hebei Province of China [H2020201298]
- S&T Program of Hebei [21323202D]
- Open Fund of Key Laboratory of Tropical Medicinal Resources Chemistry of Ministry of Education [RDZH2020001]
- Natural Science Interdisciplinary Research Program of Hebei University [DXK201913]
- Scientific Research Foundation of Hebei Educational Committee [BJ2020048]
- China Postdoctoral Science Foundation [2019M661045]
- National Training Program of Innovation and Entrepreneurship for Undergraduates [2021365, 2022218]
- High Performance Computer Center of Hebei University
Two unusual indole-diterpenoid derivatives were isolated from a marine-derived fungus, showing antiviral activity.
Oxalierpenes A and B (1 and 2), two unusual indole-diterpenoid derivatives, were obtained from the marine-derived fungus Penicillium oxalicum. The absolute configurations of 1 and 2 were elucidated by calculated TDDFT ECD and DP4plus methods. Oxalierpene A (1) represents the first indole-diterpenoid derivative with a five-membered ring of 4-hydroxy-5,5-dimethyldihydrofuran-3-one as a side chain. Oxalierpene B (2) has a unique 6/5/6/5/5/6/6/5/5 ring system. Compounds 1 and 2 showed antiviral activity against the H1N1 virus and respiratory syncytial virus (RSV), with IC50 values ranging from 2.8 to 9.4 mu M.
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