期刊
JOURNAL OF NATURAL PRODUCTS
卷 85, 期 8, 页码 2071-2081出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.2c00473
关键词
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资金
- National Natural Science Foundation of China [82173709]
- Key Science and Technology Project of Hainan Province [ZDKJ202018]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- Key-Area Research and Development Program of Guangdong Province [2020B1111030005]
- Institution of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences [ISEE2021PY05]
Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (1-7), were isolated from the marine-derived fungal strain Penicillium sp. SCSIO 41512. Compound 13 exhibited significant inhibitory activity against protein tyrosine phosphatases. Moreover, compounds 1, 2, 5, 8-10, 12, and 13 showed antibacterial activity.
Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (1-7), together with six known analogues (8-13) were isolated from the marine-derived fungal strain Penicillium sp. SCSIO 41512. Their structures were determined by extensive spectroscopic analysis, and their absolute configurations were established by single-crystal X-ray diffraction analysis and quantum chemical calculations of electronic circular dichroism spectra. Compounds 1 and 3 possess a novel decahydrofluorene-class alkaloid skeleton with a 6/5/6/8/5/6/13 and a 6/5/6/5/6/13 polycyclic system, respectively. Biologically, 13 displayed significant inhibitory activity against protein tyrosine phosphatases CD45, TCPTP, SHP1, and PTP1B with IC50 values of 8.1-17.8 mu M, and 1, 2, 5, 8- 10, 12, and 13 showed antibacterial activity against six pathogens. Their structure-activity relationship is also discussed.
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