4.7 Article

Two O-Methyltransferases Mediate Multiple Methylation Steps in the Biosynthesis of Coumarins in Cnidium monnieri

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Plant Sciences

A new P450 involved in the furanocoumarin pathway underlies a recent case of convergent evolution

Cloe Villard et al.

Summary: Furanocoumarins are phytoalexins used as an example of the arms race between plants and herbivorous insects, synthesized through a similar pathway in different plant lineages. In the fig tree, a new cytochrome P450, CYP76F112, was identified as catalyzing a unique reaction, suggesting recent emergence within the Moraceae family through lineage-specific expansion and diversification. This discovery opens new possibilities for utilizing the furanocoumarin pathway and highlights the potential of cytochromes P450 to evolve new functions for plant adaptation.

NEW PHYTOLOGIST (2021)

Review Chemistry, Medicinal

Osthole: an overview of its sources, biological activities, and modification development

Mingna Sun et al.

Summary: Osthole, a coumarin derivative found in medicinal plants, has shown multiple biological activities such as anti-tumor and anti-inflammatory effects. Research on its optimization and modification has also been conducted.

MEDICINAL CHEMISTRY RESEARCH (2021)

Review Biochemistry & Molecular Biology

Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges

Joana L. Rodrigues et al.

Summary: Furanocoumarins are plant secondary metabolites used for treating skin disorders, but extraction and purification are challenging, requiring new sustainable production schemes. While the heterologous production of simple coumarins has been demonstrated, the biosynthesis of more complex furanocoumarins remains largely unexplored.

NATURAL PRODUCT REPORTS (2021)

Review Biochemistry & Molecular Biology

Phytochemistry, Ethnopharmacology, Pharmacokinetics and Toxicology of Cnidium monnieri (L.) Cusson

Yue Sun et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Convergent evolution leading to the appearance of furanocoumarins in citrus plants

Mariana Limones-Mendez et al.

PLANT SCIENCE (2020)

Article Biochemical Research Methods

Synthesis of umbelliferone derivatives in Escherichia coli and their biological activities

Luan Luong Chu et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2017)

Review Integrative & Complementary Medicine

Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties

Yi-Min Li et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2015)

Article Plant Sciences

A methyltransferase essential for the methoxypyrazine-derived flavour of wine

Jake D. Dunlevy et al.

PLANT JOURNAL (2013)

Article Multidisciplinary Sciences

Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin

Yuheng Lin et al.

NATURE COMMUNICATIONS (2013)

Review Biochemistry & Molecular Biology

Architectures, mechanisms and molecular evolution of natural product methyltransferases

David K. Liscombe et al.

NATURAL PRODUCT REPORTS (2012)

Article Biotechnology & Applied Microbiology

Structure, function, and evolution of plant O-methyltransferases

Kevin C. Lam et al.

GENOME (2007)

Article Biochemistry & Molecular Biology

Furanocoumarin biosynthesis in Ammi majus L. -: Cloning of bergaptol O-methyltransferase

M Hehmann et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)