期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1261, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molstruc.2022.132886
关键词
Sono-photochemical; Photochemical; Zinc (II) phthalocyanine; Ruthenium complex; Singlet oxygen; Photosensitizer
This study synthesized a novel photosensitizer and calculated its singlet oxygen quantum yield using sono-photochemical methods. The results showed that the sono-photochemical method exhibited higher efficiency in singlet oxygen production when compared to the photochemical method.
Sono-photodynamic therapy (SPDT), which is used in the treatment of cancer cells and is advantageous in therapeutic results, has been studied rarely academically as it is a new method. That's why a novel multicomponent system, ZnPc-[Ru(bpy)(2)(phen)](4), as a photosensitizer (Ps) was synthesized by the condensation reaction of the symmetrical zinc phthalocyanine substituted with four 4-(4-formylphenoxy) groups at peripheral positions and ruthenium (II) bis(bipyridine)-phenanthroline complexes including amine group. The compounds were characterized by elemental analysis, FT-IR, (1) H NMR, UV-Vis and MALDI-TOF MS spectral data and analyzed for photophysico-chemical properties. Singlet oxygen quantum yields of the photosensitizer were calculated using photochemical and sono-photochemical methods. When singlet oxygen yields were compared, higher efficiencies were achieved in singlet oxygen production by the sono-photochemical method ( Phi(triangle)= 0.72 in DMSO, 0.66 in DMF) compared to the photochemical method (Phi(triangle) = 0.45 in DMSO, 0.43 in DMF). This work will lead to the synthesis of new sensitizers with high potential for use in SPDT. (c) 2022 Elsevier B.V. All rights reserved.
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