期刊
JOURNAL OF MEDICINAL FOOD
卷 25, 期 7, 页码 695-709出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2021.0100
关键词
hemiparkinsonian rats; immunohistochemical assays; neuroprotection; oxidative stress; phycocyanin; Spirulina platensis
This study found that the protein fraction from Spirulina platensis can improve behavioral impairments in hemiparkinsonian rats. It exerts neuroprotective effects through anti-inflammatory and antioxidative actions.
Spirulina platensis is a cyanobacterium with high protein content and presenting neuroprotective effects. Now, we studied a protein-enriched fraction (SPF), on behavior, neurochemical and immunohistochemical (IHC) assays in hemiparkinsonian rats, distributed into the groups: SO (sham-operated), 6-hydroxydopamine (6-OHDA), and 6-OHDA (treated with SPF, 5 and 10 mg/kg, p.o., 15 days). Afterward, animals were subjected to behavioral tests and euthanized, and brain areas used for neurochemical and IHC assays. SPF partly reversed the changes in the apomorphine-induced rotations, open field and forced swim tests, and also the decrease in striatal dopamine and 3,4-dihydroxyphenylacetic acid contents seen in hemiparkinsonian rats. Furthermore, SPF reduced brain oxidative stress and increased striatal expressions of tyrosine hydroxylase and dopamine transporter and significantly reduced hippocampal inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein expressions. The data suggest that the protein fraction from S. platensis, through its brain anti-inflammatory and antioxidative actions, exerts neuroprotective effects that could benefit patients affected by neurodegenerative diseases, like Parkinson's disease.
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