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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
Ashley R. Schneekloth et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists
Mark E. Salvati et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Selective androgen receptor modulators based on a series of 7H-[1,4] oxazino[3,2-g]quinolin-7-ones with improved in vivo activity
Yun Oliver Long et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators
Casey E. Bohl et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Discovery of a novel series of nonsteroidal androgen receptor modulators: 5-or 6-oxachrysen-2-ones
Shuo Zhao et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Pharmacology of anabolic steroids
A. T. Kicman
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
Jie Jack Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Androgen receptor is a tumor suppressor and proliferator in prostate cancer
Yuanjie Niu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease
Douglas Ashley Monks et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
(1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production
Lain-Yen Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Substituted 6-(1-Pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators
Esther Martinborough et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production
Jennifer A. Van Camp et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production
Lain-Yen Hu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
A surface on the androgen receptor that allosterically regulates coactivator binding
Eva Estebanez-Perpina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f] quinolin-8-ones
Robert I. Higuchi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Synthesis and SAR of tetrahydropyrrolo[1,2-b] [1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators
Mark C. Manfredi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Design, synthesis, and in vivo SAR of a novel series of pyrazolines as potent selective androgen receptor modulators
Xuqing Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications
James J. Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones
Robert I. Higuchi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones
Arjan van Oeveren et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Novel selective androgen receptor modulators:: SAR studies on 6-bisalkylamino-2-quinolinones
Arjan van Oeveren et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold
Raymond A. Ng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists
Raymond A. Ng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
Renee Chmelar et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives
Raymond A. Ng et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators
Xuqing Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening
James C. Lanter et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators
Lawrence G. Hamann et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold
Chongqing Sun et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators
Xuqing Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226
Feng Wang et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2006)
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
James C. Lanter et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator
Arjan van Oeveren et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer
Dong Jin Hwang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands
XQ Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity
KP De Jesus-Tran et al.
PROTEIN SCIENCE (2006)
(+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3-yl]piperazine-1-carboxamide (YM580) as an orally potent and peripherally selective nonsteroidal androgen receptor antagonist
I Kinoyama et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Cell lines used in prostate cancer research: A compendium of old and new lines - Part 1
RE Sobel et al.
JOURNAL OF UROLOGY (2005)
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists
ME Salvati et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays
E Sonneveld et al.
TOXICOLOGICAL SCIENCES (2005)
Structural basis of androgen receptor binding to selective androgen response elements
PL Shaffer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Androgen receptor signaling: Mechanism of interleukin-6 inhibition
L Jia et al.
CANCER RESEARCH (2004)
Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators
CA Marhefka et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists
A Balog et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
In vitro regulation of reporter gene transcription by the androgen receptor AF1 domain
MA Choudhry et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Bicalutamide - Clinical pharmacokinetics and metabolism
ID Cockshott
CLINICAL PHARMACOKINETICS (2004)
The androgen receptor: Structure, mutations, and antiandrogens
S Hirawat et al.
CANCER INVESTIGATION (2003)
Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone
JS Sack et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring
L Kirkovsky et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
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