期刊
JOURNAL OF MEDICAL VIROLOGY
卷 94, 期 10, 页码 4830-4838出版社
WILEY
DOI: 10.1002/jmv.27939
关键词
Delta-Omicron XD; Omicron; recombination; SARS-CoV-2
类别
资金
- Microbial Pathogenesis Training Grant [AI7323-31]
- UCLA AIDS Institute
- UCLA David Geffen School of Medicine -Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Award Program
- US National Institute of Health funds [AI069120, AI158154, AI149718, AI155232]
- China postdoctoral science foundation grants [2020T130007ZX]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2021-PT180-001]
- CAMS Innovation Fund for Medical Sciences [2021-I2M-1-061]
- National Natural Science Foundation of China [92169106]
- National Key Plan for Scientific Research and Development of China [2021YFC2301305]
- Youthful Teacher Project of Peking Union Medical College [3332019114]
- Suzhou science and technology development plan [szs2020311]
The study provides evidence of intervariant and intravariant recombination of rapidly evolving SARS-CoV-2 genomes, suggesting potential for more infectious, immune-escaping, and disease-causing Omicron and Delta-Omicron variants.
Among numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concerns, Omicron is more infectious and immune-escaping, while Delta is more pathogenic. Here, we provide evidence for both intervariant and intravariant recombination of the rapidly evolving new SARS-CoV-2 genomes, including XD/XE/XF and BA.3, raising concerns of potential more infectious, immune-escaping, and disease-causing Omicron and Delta-Omicron variants.
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