期刊
JOURNAL OF MEDICAL VIROLOGY
卷 95, 期 1, 页码 -出版社
WILEY
DOI: 10.1002/jmv.28036
关键词
molecular evolution; monkeypox; MPXV endemic; orthopoxvirus
类别
Monkeypox virus (MPXV) has been circulating in West and Central Africa. Recent outbreaks in nonendemic countries were analyzed, revealing that the MPXV-2022 strains belong to the same lineage as the 2018 strain with several new mutations. Some specific proteins were found to be more prone to mutation in the MPXV genome. This study provides insights into the ongoing MPXV outbreak and identifies novel mutations for further research.
Monkeypox virus (MPXV) has generally circulated in West and Central Africa since its emergence. Recently, sporadic MPXV infections in several nonendemic countries have attracted widespread attention. Here, we conducted a systematic analysis of the recent outbreak of MPXV-2022, including its genomic annotation and molecular evolution. The phylogenetic analysis indicated that the MPXV-2022 strains belong to the same lineage of the MPXV strain isolated in 2018. However, compared with the MPXV strain in 2018, in total 46 new consensus mutations were observed in the MPXV-2022 strains, including 24 nonsynonymous mutations. By assigning mutations to 187 proteins encoded by the MPXV genome, we found that 10 proteins in the MPXV are more prone to mutation, including D2L-like, OPG023, OPG047, OPG071, OPG105, OPG109, A27L-like, OPG153, OPG188, and OPG210 proteins. In the MPXV-2022 strains, four and three nucleotide substitutions are observed in OPG105 and OPG210, respectively. Overall, our studies illustrated the genome evolution of the ongoing MPXV outbreak and pointed out novel mutations as a reference for further studies.
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