4.7 Article

Relevant SARS-CoV-2 viremia is associated with COVID-19 severity: Prospective cohort study and validation cohort

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, General & Internal

Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines

Queenie Fernandes et al.

Summary: The emergence of novel and evolving variants of SARS-CoV-2 has created the need for newer and more adaptive diagnostic methods. However, developing rapid and sensitive diagnostic technologies has become more challenging due to emerging variants and varying symptoms. Vaccines and drugs are essential for prevention and protection, and constant development is underway. This review discusses the challenges posed by novel variants and the evolution of diagnostic techniques, as well as the development, mechanisms, advantages, and drawbacks of vaccines and drugs and their immunological impact.

ANNALS OF MEDICINE (2022)

Article Biochemical Research Methods

Evaluation of two RT-PCR techniques for SARS-CoV-2 RNA detection in serum for microbiological diagnosis

Alexandra Martin Ramirez et al.

Summary: This study evaluated the ability of two commercial reverse real-time-PCR (rRT-PCR) tests to detect SARS-CoV-2 RNA in the serum of COVID-19 patients. The tests showed high specificity and positive predictive value, but lower sensitivity and negative predictive value. The detection of SARS-CoV-2 viremia using these tests can be a useful tool for stratifying COVID-19 patients and can be implemented in microbiology laboratories.

JOURNAL OF VIROLOGICAL METHODS (2022)

Article Immunology

SARS-CoV-2 RNAemia Predicts Clinical Deterioration and Extrapulmonary Complications from COVID-19

Nikhil Ram-Mohan et al.

Summary: Measurement of SARS-CoV-2 RNA from the plasma of COVID-19 patients using digital polymerase chain reaction can predict disease severity, clinical deterioration, and extrapulmonary complications. It may guide patient triage and management effectively.

CLINICAL INFECTIOUS DISEASES (2022)

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes

Jana L. Jacobs et al.

Summary: This study found that SARS-CoV-2 vRNA was detected in the plasma of COVID-19 patients, with the highest rates in ICU patients. Higher levels of vRNA were associated with more severe disease, patient outcomes, and specific inflammatory biomarkers.

CLINICAL INFECTIOUS DISEASES (2022)

Article Infectious Diseases

Duration of SARS-CoV-2 viremia and its correlation to mortality and inflammatory parameters in patients hospitalized for COVID-19: a cohort study

Karl Hagman et al.

Summary: SARS-CoV-2 viremia at admission is associated with high risk for mortality. The duration of viremia is a significant factor in predicting mortality, with a 40% increased odds for each additional day of viremia.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2022)

Article Virology

Usefulness of real-time RT-PCR to understand the kinetics of SARS-CoV-2 in blood: A prospective study

Nelly Daniela Zurita-Cruz et al.

Summary: This study found that persistent SARS-CoV-2 viremia is associated with poor clinical outcomes in hospitalized COVID-19 patients. Patients with persistent viremia had higher viral loads, but the duration of persistence was relatively short.

JOURNAL OF CLINICAL VIROLOGY (2022)

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 RNA in Plasma Is Associated With Intensive Care Unit Admission and Mortality in Patients Hospitalized With Coronavirus Disease 2019

Christian Prebensen et al.

Summary: Detection of severe acute respiratory syndrome coronavirus 2 RNA in the circulation may be associated with disease severity and poor outcomes in patients hospitalized with coronavirus disease 2019.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

High Frequency of SARS-CoV-2 RNAemia and Association With Severe Disease

Catherine A. Hogan et al.

Summary: This study examined the presence of SARS-CoV-2 RNA in plasma of COVID-19 patients and found an association between RNAemia and clinical severity. A high proportion of RNAemia was detected, with all deaths occurring in patients with detectable RNAemia.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 RNA in Serum as Predictor of Severe Outcome in Coronavirus Disease 2019: A Retrospective Cohort Study

Karl Hagman et al.

Summary: Detection of SARS-CoV-2 RNA in serum at hospital admission is associated with a higher risk of progression to critical disease and death in COVID-19 patients. Positive results indicate a poorer outcome.

CLINICAL INFECTIOUS DISEASES (2021)

Article Immunology

Highly Sensitive Quantification of Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Sheds Light on its Potential Clinical Value

David Veyer et al.

Summary: This study analyzed 58 COVID-19 patients and found that 74.1% had SARS-CoV-2 RNAemia, which correlated with disease severity. Levels of SARS-CoV-2 RNAemia were associated with severity, suggesting that it could be a potential prognostic marker for COVID-19 patients.

CLINICAL INFECTIOUS DISEASES (2021)

Article Allergy

IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study

Jose Maria Galvan-Roman et al.

Summary: Baseline IL-6 greater than 30 pg/mL predicts the need for IMV in COVID-19 patients, and early TCZ treatment can improve oxygenation. Patients with high IL-6 not treated with TCZ show high mortality.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Pathology

Dynamics of Blood Viral Load Is Strongly Associated with Clinical Outcomes in Coronavirus Disease 2019 (COVID-19) Patients A Prospective Cohort Study

Liting Chen et al.

Summary: In this study using RT-ddPCR, it was found that 92.3% of COVID-19 patients had viremia in their blood. The blood viral load was significantly higher in critical patients compared to general and severe patients, indicating a potential correlation with disease severity.

JOURNAL OF MOLECULAR DIAGNOSTICS (2021)

Article Infectious Diseases

SARS-CoV-2 RNA in plasma samples of COVID-19 affected individuals: a cross-sectional proof-of-concept study

Luna Colagrossi et al.

Summary: This proof-of-concept study of 41 SARS-CoV-2-positive adult individuals revealed that patients with viremia had a higher mortality rate, were more frequently affected by haematological malignancies, and had higher viral loads in respiratory samples. This highlights the importance of early identification of high-risk patients for severe COVID-19, particularly among haematologic patients.

BMC INFECTIOUS DISEASES (2021)

Review Infectious Diseases

Clinical efficacy and safety of remdesivir in patients with COVID-19: a systematic review and network meta-analysis of randomized controlled trials

Chih-Cheng Lai et al.

Summary: The study found that remdesivir can improve the clinical outcomes of patients with COVID-19, with a 5-day regimen likely being sufficient. However, no mortality benefit was observed with remdesivir treatment, and there was no increased risk of adverse events.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2021)

Article Immunology

SARS-CoV-2 Blood RNA Load Predicts Outcome in Critically Ill COVID-19 Patients

Fabian Heinrich et al.

Summary: The study found that in critically ill COVID-19 patients, blood SARS-CoV-2 RNA load can serve as a prognostic factor, with significantly higher levels in non-survivors upon ICU admission and a higher probability of blood RNA clearance failure. Blood RNA load represents an important independent predictor of outcome for critically ill COVID-19 patients, with a higher impact on survival compared to respiratory tract SARS-CoV-2 RNA loads.

OPEN FORUM INFECTIOUS DISEASES (2021)

Article Microbiology

SARS-CoV-2 E Gene Variant Alters Analytical Sensitivity Characteristics of Viral Detection Using a Commercial Reverse Transcription-PCR Assay

Stephen Tahan et al.

Summary: Diagnostic assays for detecting SARS-CoV-2 are essential for patient management and infection prevention. Mutations can affect the accuracy of these assays, highlighting the importance of using dual-target assays to reduce false-negative results.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

Letter Infectious Diseases

SARS-CoV-2 RNAemia is associated with severe chronic underlying diseases but not with nasopharyngeal viral load

Judith Berastegui-Cabrera et al.

JOURNAL OF INFECTION (2021)

Article Multidisciplinary Sciences

The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients

Josef D. Jarhult et al.

Summary: The study found that approximately 34% of COVID-19 ICU patients had SARS-CoV-2 RNAemia. Patients with RNAemia had higher rates of renal replacement therapy and mortality, but biomarkers for extra-pulmonary organ failure and extent of organ failure were similar compared to those without RNAemia.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

Clemens Gutmann et al.

Summary: Prognostic characteristics for ICU COVID-19 patients can be determined using blood samples, with RNAemia and pentraxin-3 identified as predictors of 28-day ICU mortality. Additionally, galectin-3-binding protein is found to interact with the SARS-CoV-2 spike glycoprotein and exhibit antiviral properties.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients

Diego A. Rodriguez-Serrano et al.

Summary: The study analyzed SARS-CoV-2 RNA detection in serum as a severity biomarker in COVID-19 patients. Viremia assessment at admission is the most useful biomarker for predicting mortality in COVID-19 patients.

SCIENTIFIC REPORTS (2021)

Editorial Material Cardiac & Cardiovascular Systems

COVID-19 illness in native and immunosuppressed states: A clinical?therapeutic staging proposal

Hasan K. Siddiqi et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

Review Medicine, Research & Experimental

The role of biomarkers in diagnosis of COVID-19-A systematic review

Muhammed Kermali et al.

LIFE SCIENCES (2020)

Review Pharmacology & Pharmacy

Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review

Fabrizio Cantini et al.

Article Critical Care Medicine

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Jesus F. Bermejo-Martin et al.

CRITICAL CARE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Jesse Fajnzylber et al.

NATURE COMMUNICATIONS (2020)