4.7 Article

Association between COVID-19 and telomere length: A bidirectional Mendelian randomization study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

Understanding the role of telomere attrition and epigenetic signatures in COVID-19 severity

Ata Mahmoodpoor et al.

Summary: The COVID-19 outbreak has posed an unprecedented threat to global health systems. The disease has diverse clinical presentations, ranging from asymptomatic cases to severe respiratory failure. Older patients are at a higher risk of developing severe forms of COVID-19, possibly due to age-dependent immune response patterns. Telomere length and epigenetic mechanisms are believed to play a role in the severity of COVID-19, with shorter telomeres associated with a higher risk of severe outcomes.
Review Medical Laboratory Technology

Role of senescence in the chronic health consequences of COVID-19

Erin O. Wissler Gerdes et al.

Summary: COVID-19 can have long-lasting effects on patients, known as Long-Hauler's Syndrome. Older adults are at greater risk for severe outcomes. The aging process may interfere with defenses against viral infection and contribute to increased risk for long-term COVID-19 sequelae. Senolytics and other geroscience interventions may be an option for delaying, preventing, or alleviating Long-Hauler's Syndrome.

TRANSLATIONAL RESEARCH (2022)

Article Cell Biology

Shorter telomere lengths in patients with severe COVID-19 disease

Raul Sanchez-Vazquez et al.

Summary: Shorter telomeres are associated with increased severity of COVID-19, particularly in older patients. This suggests that molecular pathways related to aging play a role in the disease's progression.

AGING-US (2021)

Review Cell Biology

The role of extracellular DNA in COVID-19: Clues from inflamm-aging

Gianluca Storci et al.

Summary: Elderly men with age-related diseases have a severe prognosis and high mortality rate from COVID-19, associated with hyper-inflammation. Extracellular DNA, particularly mitochondrial DNA, is seen as a trigger of the inflammatory response, while telomeric DNA may inhibit inflammatory pathways. The depletion of telDNA reservoir and the increase in extracellular mtDNA in elderly men affected by COVID-19 may explain hyper-inflammation, reminiscent of inflamm-aging.

AGEING RESEARCH REVIEWS (2021)

Article Genetics & Heredity

Polygenic basis and biomedical consequences of telomere length variation

Veryan Codd et al.

Summary: This study characterized the genetic architecture of leukocyte telomere length in UK Biobank participants and identified 197 sentinel variants associated with LTL at 138 genomic loci. Genetically determined differences in LTL were found to be associated with various biological traits and diseases, and individuals with shorter LTL had a lower life expectancy compared to those with longer LTL. The findings provide insights into the genetic regulation of LTL, as well as its impact on physiological traits, diseases, and longevity.

NATURE GENETICS (2021)

Article Geriatrics & Gerontology

The Nexus Between Telomere Length and Lymphocyte Count in Seniors Hospitalized With COVID-19

Athanase Benetos et al.

Summary: The study found that in COVID-19 patients, lymphocyte count is correlated with telomere length, while there is no such correlation in non-COVID-19 patients. Older individuals may reach the limits of their telomere reserves when infected with SARS-CoV-2.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

Review Endocrinology & Metabolism

Diabetes, metabolic disease, and telomere length

Feifei Cheng et al.

Summary: Telomeres, repetitive nucleotide sequences at chromosome ends, serve as markers for DNA damage and biological ageing, associated with cardiovascular disease, diabetes, and cancer. Studies focus on genetic and environmental influences on telomere length regulation, emphasizing the need for further research to understand the link between diabetes and telomere length.

LANCET DIABETES & ENDOCRINOLOGY (2021)

Article Cell Biology

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

Gustavo Garcia et al.

Summary: A novel medium-throughput drug-screening system was developed to identify potential drug candidates that can effectively inhibit SARS-CoV-2 infection. Through drug-protein interaction-based screening, promising kinase inhibitors were discovered as host-directed therapy for treating coronavirus infections, highlighting important mechanisms of host-pathogen interactions.

CELL REPORTS (2021)

Article Cell Biology

Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening

Elisia D. Tichy et al.

Summary: Repeated cycles of damage and repair in muscle disorders like DMD can lead to inefficiency in muscle stem cell response. The early telomere shortening in diseased MuSCs is associated with aberrant NF-kappa B activation, leading to severe skeletal muscle defects. NF-kappa B plays a role in regulating stem-cell-specific telomere length and could be a common mechanism in diseases characterized by chronic inflammation.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

SARS-CoV-2 triggers DNA damage response in Vero E6 cells

Joshua Victor et al.

Summary: SARS-CoV-2 infection may trigger a DNA damage response in host cells, leading to telomere shortening and reduced expression of the TRF2 shelterin-protein complex.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors

Alessia Mongelli et al.

Summary: COVID-19 infection leads to a range of severe sequelae, including a significant increase in biological age and telomere shortening. These sequelae are particularly pronounced in younger patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Mapping the human genetic architecture of COVID-19

Mari E. K. Niemi et al.

Summary: The genetic make-up of an individual plays a role in susceptibility and response to viral infections. A global network of researchers identified 13 significant genetic loci associated with SARS-CoV-2 infection and severe COVID-19 cases. Mendelian randomization analyses suggest a causal role for smoking and body-mass index in severe COVID-19. Collaboration among human genetics researchers has allowed for the discovery of novel host genetic factors linked to COVID-19.

NATURE (2021)

Article Medicine, General & Internal

Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank

Qingning Wang et al.

Summary: The study suggests that shorter leukocyte telomere length is associated with a higher risk of adverse COVID-19 outcomes, independent of major risk factors including age. Further research is needed to determine whether this association reflects causality.

EBIOMEDICINE (2021)

Article Biochemistry & Molecular Biology

Shorter leukocyte telomere length is associated with severity of COVID-19 infection.

Gabriel Arantes dos Santos et al.

Summary: The study compared leukocyte telomere length (LTL) in patients with different clinical severity of COVID-19 and found that shorter telomere length was significantly associated with disease severity. The severe group had older patients with an increase in hypertension and diabetes. This suggests that telomere length could be a potential biomarker for disease severity and understanding the pathophysiology of SARS-CoV-2.

BIOCHEMISTRY AND BIOPHYSICS REPORTS (2021)

Correction Medicine, General & Internal

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy (vol 323, pg 1574, 2020)

G. Grasselli et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Virology

Coronavirus disease (COVID-19) and neonate: What neonatologist need to know

Qi Lu et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Review Biochemistry & Molecular Biology

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

Francesca Coperchini et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Article Public, Environmental & Occupational Health

Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020

Stephanie Bialek et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

Article Pediatrics

Epidemiology of COVID-19 Among Children in China

Yuanyuan Dong et al.

PEDIATRICS (2020)

Article Cell Biology

Short telomeres increase the risk of severe COVID-19

Antoine Froidure et al.

AGING-US (2020)

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Environmental Sciences

Urban Air Pollution Particulates Suppress Human T-Cell Responses to Mycobacterium Tuberculosis

Olufunmilola Ibironke et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

Article Public, Environmental & Occupational Health

Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression

Jack Bowden et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2018)

Article Medicine, General & Internal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Article Medicine, General & Internal

Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M. Davies et al.

BMJ-BRITISH MEDICAL JOURNAL (2018)

Review Environmental Sciences

Cigarette smoking and telomere length: A systematic review of 84 studies and meta-analysis

Yuliana Astuti et al.

ENVIRONMENTAL RESEARCH (2017)

Article Public, Environmental & Occupational Health

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2017)

Editorial Material Medicine, General & Internal

Mendelian Randomization

Connor A. Emdin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

Review Medicine, General & Internal

Cellular Senescence: A Translational Perspective

James L. Kirkland et al.

EBIOMEDICINE (2017)

Article Public, Environmental & Occupational Health

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2015)

Article Biochemistry & Molecular Biology

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

George Davey Smith et al.

HUMAN MOLECULAR GENETICS (2014)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Biochemistry & Molecular Biology

Meta-analysis of telomere length in 19 713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

Linda Broer et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2013)

Article Public, Environmental & Occupational Health

Avoiding bias from weak instruments in Mendelian randomization studies

Stephen Burgess et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2011)

Article Mathematical & Computational Biology

Bias in causal estimates from Mendelian randomization studies with weak instruments

Stephen Burgess et al.

STATISTICS IN MEDICINE (2011)

Review Mathematical & Computational Biology

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Debbie A. Lawlor et al.

STATISTICS IN MEDICINE (2008)

Article Hematology

White cell telomere length and risk of premature myocardial infarction

S Brouilette et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2003)