☆ 4.7 Review

Hydrogels for bone organoid construction: From a materiobiological perspective

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2023)

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Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair

Bobin Mi et al.

Summary: The ratios of osteoblast/osteoclast and M1/M2 macrophages are crucial for fracture healing. This study developed a cocktail therapy to simultaneously regulate the balance of these cells, leading to enhanced fracture repair. Each component of the cocktail therapy was found to be indispensable, providing insight into synergistic strategies for fracture repair.

ACS NANO (2022)

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Article Engineering, Biomedical

Sodium alginate microencapsulation of human mesenchymal stromal cells modulates paracrine signaling response and enhances efficacy for treatment of established osteoarthritis

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Summary: The study evaluated the effects of sodium alginate microencapsulation on human MSCs in treating OA, and found that encapsulated MSCs can reduce cartilage degeneration and bone remodeling. In response to IL-1 beta stimulation, encapsulated MSCs showed a targeted secretory response, while nonencapsulated MSCs showed an indiscriminate increase in cytokines.

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Article Engineering, Biomedical

A poly(ethylene glycol) three-dimensional bone marrow hydrogel

Lauren E. E. Jansen et al.

Summary: Three-dimensional hydrogels made from synthetic polymers can mimic the extracellular matrix (ECM) of real tissues, but they have limitations in terms of the diversity and specificity of bioactive peptides. To overcome these limitations, researchers have developed a bone marrow hydrogel that incorporates the complex and specific protein signature of bone marrow. This tissue-centric approach allows for better replication of the elasticity and structure of bone marrow, and provides a wide range of bone marrow-specific and cell-instructive peptides.

BIOMATERIALS (2022)

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Article Chemistry, Applied

Collagen and nano-hydroxyapatite interactions in alginate-based microcapsule provide an appropriate osteogenic microenvironment for modular bone tissue formation

Ayla Hassani et al.

Summary: Addition of nano-hydroxyapatite and collagen to alginate microcapsule hydrogel improved osteoblasts viability, reduced swelling and degradation ratios, and increased compressive strength. In addition, calcium deposits, increased intracellular calcium and alkaline phosphatase activity were found in the Alg-nHA-Col hydrogel.

CARBOHYDRATE POLYMERS (2022)

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Review Materials Science, Multidisciplinary

Bacterial anti-adhesion surface design: Surface patterning, roughness and wettability: A review

Kun Yang et al.

Summary: Bacterial adhesion and biofilm formation pose significant challenges to the medical system and food safety. Anti-adhesion surface designs have been developed to reduce bacterial attachment, with modifications in surface pattern and roughness showing effectiveness in minimizing contact area and weakening initial adhesion forces.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2022)

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Article Engineering, Biomedical

4D biofabrication via instantly generated graded hydrogel scaffolds

Aixiang Ding et al.

Summary: This article introduces a simple method for generating adjustable and robust gradients for 4D biofabrication using a single- or multi-material one-step fabrication strategy. By photocrosslinking a mixed solution, a cell-laden gradient hydrogel with pre-programmable deformation can be created. This method can be applied to various polymers and can be integrated with other hydrogel-engineering techniques to fabricate more advanced cell-laden scaffold structures.

BIOACTIVE MATERIALS (2022)

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The horizon of bone organoid: A perspective on construction and application

Shuangshuang Chen et al.

Summary: The repair and regeneration of bone defects caused by various factors have always been a key issue in clinical practice. Bone tissue engineering technology has greatly accelerated the speed and quality of bone regeneration by providing functional scaffold materials and seed cells. However, the complicated bone metabolism mechanism poses challenges to research in bone regeneration. Organoids, as a new concept, show promising application prospects in organ development, drug screening, and mechanism study.

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Bioactive injectable composites based on insulin-functionalized silica particles reinforced polymeric hydrogels for potential applications in bone tissue engineering

Aleksandra Krajcer et al.

Summary: Novel bioactive injectable composites based on biopolymeric hydrogels reinforced with insulin-functionalized silica particles were synthesized and their potential for bone defect regeneration was demonstrated through in vitro experiments.

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Lysine-functionalized chondroitin sulfate improves the biological properties of collagen/chitosan-based injectable hydrogels

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Summary: This study presents a novel injectable hydrogel composed of collagen, chitosan, and lysine-functionalized chondroitin sulfate. The physicochemical and biological properties of the hydrogels can be adjusted by varying the concentrations of the components. The addition of lysine moieties to chondroitin sulfate enhances the bioactivity of the hydrogels and promotes cell proliferation and adhesion. These hydrogels have great potential for tissue engineering applications.

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Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair

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BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering

Xu Xue et al.

Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.

BIOACTIVE MATERIALS (2022)

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Article Materials Science, Multidisciplinary

Precipitation and coarsening kinetics of H-phase in NiTiHf high temperature shape memory alloy

A. Shuitcev et al.

Summary: This paper investigates the precipitation, coarsening, and age hardening of H-phase precipitates in NiTiHf high-temperature shape memory alloys. A Time-Temperature-Transformation diagram is constructed based on precipitation kinetics, and the critical size of precipitates for breaking down the precipitate/matrix interface coherency is estimated. The study provides insights into enhancing strain recovery properties in these alloys.

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Injectable composite hydrogel based on carbon particles for photothermal therapy of bone tumor and bone regeneration

Chengxiong Wei et al.

Summary: An injectable composite hydrogel with temperature sensitivity is developed for the treatment of bone tumor and bone regeneration, achieving a balance between complete removal of tumor tissue and maximum preservation of healthy bone tissue. The hydrogel exhibits significant ablation of human osteosarcoma and promotes new bone formation.

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Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant

Ze Lin et al.

Summary: This study demonstrates the use of PD-L1-enriched exosomes for bone fracture repair and highlights the potential of Hydrogel@Exos systems for bone fracture therapy through immune inhibitory effects. The results show that exosomal PD-L1 can inhibit T cell activation and promote osteogenic differentiation of mesenchymal stem cells. Additionally, embedding exosomes in a hydrogel allows for time-released delivery and improves treatment efficacy.

BIOACTIVE MATERIALS (2022)

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Silk fibroin-based biomaterials for cartilage/osteochondral repair

Ziyang Zhou et al.

Summary: Osteoarthritis is a common joint disease that causes physical and psychological harm to patients and burdens the healthcare system. Tissue engineering has been focusing on cartilage repair, with silk fibroin as a promising biomaterial due to its unique properties and capabilities for functional modification.

THERANOSTICS (2022)

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Influence of viscosity on chondrogenic differentiation of mesenchymal stem cells during 3D culture in viscous gelatin C solution-embedded hydrogels

Kyubae Lee et al.

Summary: This study utilized a 3D culture system with viscous gelatin solutions to investigate the influence of viscosity on the chondrogenic differentiation of hMSCs. The results showed that high viscosity gelatin solutions promoted cell proliferation and increased production of cartilaginous matrix, suggesting that viscosity is a dominant mechanical cue affecting stem cell differentiation.

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2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside promotes the effects of dental pulp stem cells on rebuilding periodontal tissues in experimental periodontal defects

Chi-Yu Lin et al.

Summary: The findings of this study suggest that THSG-treated human dental pulp stem cells have significant regenerative effects in the healing of periodontal defects in rats. They promote new bone formation, increase the periodontal bone supporting ratio, enhance cell recruitment, and possibly angiogenesis.

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Summary: Novel multifunctional biomimetic injectable hybrid systems have been synthesized, showing promise for bone tissue regeneration. These systems can be injected precisely into diseased tissue, serving as scaffolds for locally controlled bone tissue regeneration and remodeling while maintaining optimal bone cell levels. They are especially useful for repairing small osteoporotic bone defects and lack systemic toxicity.

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Bioinspired stratified electrowritten fiber-reinforced hydrogel constructs with layer-specific induction capacity for functional osteochondral regeneration

Zhiguang Qiao et al.

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Self-renewal or quiescence? Orchestrating the fate of mesenchymal stem cells by matrix viscoelasticity via PI3K/Akt-CDK1 pathway

Chuanchuan Lin et al.

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A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction

Panpan Pan et al.

Summary: A novel injectable and self-healing nano hybrid hydrogel was prepared in this study, showing controllable mechanical strength, degradation, and swelling behavior by adjusting the molar ratio of raw materials. The hydrogel exhibited pH responsiveness, good degradability, and biocompatibility, making it an ideal candidate for bone tissue regeneration and drug delivery applications.

CHINESE CHEMICAL LETTERS (2021)

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Protein-Functionalized Poly(ethylene glycol) Hydrogels as Scaffolds for Monolayer Organoid Culture

Reid L. Wilson et al.

Summary: Organoids derived from stem cells have the ability to recreate complex physiological and pathophysiological processes, making them attractive targets for tissue engineering. This study presents a method to create monolayer organoid cultures on PEG hydrogel scaffolds using intestinal epithelial organoids as a proof-of-concept. The approach involves functionalizing the hydrogel with poly(D-lysine) to allow the adsorption of basement membrane proteins, successfully mediating the formation of monolayer IEOs.

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Synergic adhesive chemistry-based fabrication of BMP-2 immobilized silk fibroin hydrogel functionalized with hybrid nanomaterial to augment osteogenic differentiation of rBMSCs for bone defect repair

Bo Wang et al.

Summary: This study developed a dopamine adhesive chemistry-based silk fibroin hydrogel with nano-hydroxyapatite-graphene oxide hybrid nanofillers and immobilized bone morphogenic protein-2, which effectively promoted in vitro compatibility with rabbit bone marrow derived mesenchymal stem cells and in vivo new bone regrowth. Bone-specific hydrogel scaffolds with upgraded structural features and mechanical properties were achieved, showing promising results for new generation bone regeneration therapies.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Injectable eggshell-derived hydroxyapatite-incorporated fibroin-alginate composite hydrogel for bone tissue engineering

Piyachat Chuysinuan et al.

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The nuclear piston activates mechanosensitive ion channels to generate cell migration paths in confining microenvironments

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Hydrogel mechanics are a key driver of bone formation by mesenchymal stromal cell spheroids

Jacklyn Whitehead et al.

Summary: Research shows that leveraging the mechanical properties of alginate hydrogels can enhance the osteogenic potential of entrapped MSC spheroids. Compared to elastic alginate, calcium deposition of MSC spheroids was increased in ionically crosslinked, viscoelastic hydrogels.

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A guide to the composition and functions of the extracellular matrix

Nikos K. Karamanos et al.

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Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction

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A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model

Guangyao Jiang et al.

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ACTA BIOMATERIALIA (2021)

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Ary Marsee et al.

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Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-β1-Releasing PLGA Microcarrier

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Magnesium alloy based interference screw developed for ACL reconstruction attenuates peri-tunnel bone loss in rabbits

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Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications

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Repair of full-thickness articular cartilage defect using stem cell encapsulated thermogel

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Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling

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Enhanced calcium ion mobilization in osteoblasts on amino group containing plasma polymer nanolayer

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RNA-seq reveals diverse effects of substrate stiffness on mesenchymal stem cells

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Off-the-Shelf Biomimetic Graphene Oxide-Collagen Hybrid Scaffolds Wrapped with Osteoinductive Extracellular Matrix for the Repair of Cranial Defects in Rats

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Collagen coated electrospun polyethersulfon nanofibers improved insulin producing cells differentiation potential of human induced pluripotent stem cells

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Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications

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FRONTIERS IN CHEMISTRY (2018)

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Effect of microporosity on scaffolds for bone tissue engineering

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REGENERATIVE BIOMATERIALS (2018)

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A review of fibrin and fibrin composites for bone tissue engineering

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INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements

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Controlled release of vancomycin from 3D porous graphene-based composites for dual-purpose treatment of infected bone defects

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Effects of mesoporous calcium magnesium silicate on setting time, compressive strength, apatite formation, degradability and cell behavior to magnesium phosphate based bone cements

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Translating the role of osteogenic-angiogenic coupling in bone formation: Highly efficient chitosan-pDNA activated scaffolds can accelerate bone regeneration in critical-sized bone defects

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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

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Supramolecular Hydrogels Based on DNA Self-Assembly

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Hydrogels with tunable stress relaxation regulate stem cell fate and activity

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Nanomechanics of Type I Collagen

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Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications

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3D Bioplotting of Gelatin/Alginate Scaffolds for Tissue Engineering: Influence of Crosslinking Degree and Pore Architecture on Physicochemical Properties

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Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

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Bioactive polymeric scaffolds for tissue engineering

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Linking naturally and unnaturally spun silks through the forced reeling of Bombyx mori

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ACTA BIOMATERIALIA (2015)

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A bio-inspired, microchanneled hydrogel with controlled spacing of cell adhesion ligands regulates 3D spatial organization of cells and tissue

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BIOMATERIALS (2015)

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The Role of Collagen Organization on the Properties of Bone

Patrick Garnero

CALCIFIED TISSUE INTERNATIONAL (2015)

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Review Endocrinology & Metabolism

Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease

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CALCIFIED TISSUE INTERNATIONAL (2015)

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Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections

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INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2015)

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ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6 (2015)

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Synthetic Mimics of the Extracellular Matrix: How Simple is Complex Enough?

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ANNALS OF BIOMEDICAL ENGINEERING (2015)

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Synthesis of composite gelatin-hyaluronic acid-alginate porous scaffold and evaluation for in vitro stem cell growth and in vivo tissue integration

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COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Bone Quality: The Determinants of Bone Strength and Fragility

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SPORTS MEDICINE (2014)

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Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment

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SCIENTIFIC REPORTS (2014)

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Comparison of micro- vs. nanostructured colloidal gelatin gels for sustained delivery of osteogenic proteins: Bone morphogenetic protein-2 and alkaline phosphatase

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Silk ionomers for encapsulation and differentiation of human MSCs

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MAMMALIAN MAPK SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY STRESS AND INFLAMMATION: A 10-YEAR UPDATE

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Review Oncology

Multiple uses of basement membrane-like matrix BME/Matrigel) in vitro and in vivo with cancer cells

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INTERNATIONAL JOURNAL OF CANCER (2011)

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Removal of lactate dehydrogenase-elevating virus from human-in-mouse breast tumor xenografts by cell-sorting

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Hydrolytically Degradable Poly(Ethylene Glycol) Hydrogel Scaffolds with Tunable Degradation and Mechanical Properties

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Matrigel: A complex protein mixture required for optimal growth of cell culture

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Tuning of cell proliferation on tough gels by critical charge effect

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2009)

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Letter Pathology

To Matrigel or not to Matrigel

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AMERICAN JOURNAL OF PATHOLOGY (2008)

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Gelatin: The Paramount food additive

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FOOD REVIEWS INTERNATIONAL (2003)

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