Editorial for Inversion-Recovery-Prepared Oscillating Gradient Sequence Improves Diffusion-Time Dependency Measurements in the Human Brain

Article Radiology, Nuclear Medicine & Medical Imaging

Inversion-Recovery-Prepared Oscillating Gradient Sequence Improves Diffusion-Time Dependency Measurements in the Human Brain

Haotian Li et al.

Summary: This study aimed to assess the effect of cerebrospinal fluid (CSF) on diffusion magnetic resonance imaging (dMRI) measurements and investigate the efficacy of inversion-recovery prepared oscillating and pulsed gradient sequences in improving the measurements. The results showed that the inversion-recovery prepared sequences effectively suppressed the CSF partial volume effect and significantly enhanced the measurements in the human brain.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diffusion-prepared 3D gradient spin-echo sequence for improved oscillating gradient diffusion MRI

Dan Wu et al.

Summary: The study proposed a 3D oscillating gradient-prepared gradient spin-echo sequence for OG dMRI on clinical scanners, which improved SNR, reduced scan time, and minimized image distortion compared to 2D multislice acquisition. The new sequence showed higher SNR and shorter scan time for relatively thick slice coverage, leading to improved diffusion-tensor reconstruction and reduced image distortion. Additionally, diffusion-time dependency was observed in both white and gray matter of the human brain using the new sequence.

MAGNETIC RESONANCE IN MEDICINE (2021)

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Article Clinical Neurology

Time-dependent diffusion MRI probes cerebellar microstructural alterations in a mouse model of Down syndrome

Dan Wu et al.

Summary: The study demonstrated the superior sensitivity of utilizing oscillating gradient dMRI to detect cerebellar microstructural changes in Down syndrome mice. The detection sensitivity increased with oscillating frequency, and the t(d)-dependence was reduced in Ts65Dn mice, likely due to altered granule cell density and abnormal dendritic arborization of Purkinje cells. These findings suggest the potential application of this technique in cerebellar disorders.

BRAIN COMMUNICATIONS (2021)

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Article Anatomy & Morphology