期刊
JOURNAL OF INFECTIOUS DISEASES
卷 226, 期 SUPPL 1, 页码 S45-S54出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiac163
关键词
respiratory syncytial virus; disease severity; wheezing; subgroup; viral load
资金
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- NIHR Thames Valley and South Midlands Clinical Research Network
- British Research Council
- Innovative Medicines Initiative 2 Joint Undertaking [116019]
- European Union
- European Federation of Pharmaceutical Industries and Associations
- Respiratory Syncytial Virus Consortium in Europe (RESCEU) project
The study evaluated the association between the severity of RSV disease and host age, viral load, and RSV subtypes. Younger infants were more likely to have severe RSV disease, while older infants, higher viral load, and RSV-A were associated with fever. RSV-A and RSV-B caused similar disease severity.
Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in infants and young children worldwide. Here we evaluated host demographic and viral factors associated with RSV disease severity in 325 RSV-infected infants under 1 year of age from 3 European countries during 2017-2020. Younger infants had a higher clinical severity (ReSViNET) score and were more likely to require hospitalization, intensive care, respiratory support, and/or mechanical ventilation than older infants (<3 months vs 3 to <6 months and 3 to <6 months vs >= 6 months). Older age (>= 6 months vs <3 months), higher viral load, and RSV-A were associated with a greater probability of fever. RSV-A and RSV-B caused similar disease severity and had similar viral dynamics. Infants with a more severe RSV infection, demonstrated by having a higher ReSViNET score, fever, and requiring hospitalization and intensive care, were more likely to have developed subsequent wheezing at 1 year of age.
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