期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 114, 期 -, 页码 418-426出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2022.07.032
关键词
Fentanyl; Multi-Walled Carbon Nanotube; Hydroxyapatite; Metal-Organic Framework
资金
- National Institute for Medical Research Development [996152]
- Shahid Rajaee Teacher Training University, Tehran, Iran
A new electrochemical sensor has been developed to accurately measure fentanyl by measuring its oxidation current in aqueous solutions. The study demonstrates that a glassy carbon electrode modified with a nanocomposite of multi-walled carbon nanotube, hydroxyapatite, and copper-based metal-organic framework (MWCNT-HA/Cu-H3BTC) (GCE/MWCNT-HA/Cu-H3BTC) can achieve sensitive detection of fentanyl, with excellent reproducibility and stability.
Fentanyl is a potent narcotic drug with the same effects as morphine or heroin, but it's significantly more potent than these drugs. That means a tiny dose can have a dangerous impact and is also lethal, so it is essential to measure it. In this work, we have developed a new electrochemical sensor to measure this deadly drug utilizing a nanocomposite of multi-walled carbon nanotube, hydroxyapatite, and copper -based metal-organic framework (MWCNT-HA/Cu-H3BTC). The nanocomposite was first examined by X-ray diffraction, field emission scanning electron, Infrared, and Raman spectroscopic techniques. The glassy carbon electrode (GCE) modified with MWCNT-HA/Cu-H3BTC was employed to determine fentanyl in aqueous solutions. The highest oxidation current was generated for fentanyl at GCE/MWCNT-HA/Cu-H3BTC compared to the GCE, GCE/MWCNT, GCE/MWCNT/HA, and GCE/Cu-H3BTC. The GCE/MWCNT-HA/ Cu-H3BTC showed a linear relationship between the concentration and the oxidation current of fentanyl in the 0.01 to 100 mu M with a detection limit of 3 nM. Finally, the fentanyl quantification in blood serum samples was successfully performed. The GCE/MWCNT-HA/Cu-H3BTC's reproducibility and stability were indeed excellent. (C) 2022 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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